Pravastatin reduces steroid-induced osteonecrosis of the femoral head in SHRSP rats.
Pravastatin reduces steroid-induced osteonecrosis of the femoral head in SHRSP rats.
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DOI：
10.3109/17453674.2011.641103
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发表时间：
2012-02
影响因子：
3.7
通讯作者：
Niwa M
中科院分区：
文献类型：
--
作者：
Nozaki Y;Kumagai K;Miyata N;Niwa M
虽然激素性股骨头坏死（ONFH）的确切原因尚不清楚，但外周循环衰竭、脂质代谢紊乱和氧化应激增加被认为是可能的原因。我们研究了普伐他汀作为他汀类药物治疗是否能降低（1）股骨头坏死的发生率，（2）脂肪细胞面积，（3）股骨头骨髓变化。 将81只13周龄自发性高血压卒中倾向（SHRSP）/Izm雄性大鼠分为4组：对照组（C组）、普伐他汀组（P组）、类固醇组（S组）和普伐他汀+类固醇组（PS组）。在15周龄时给予类固醇。普伐他汀作为他汀类药物，在饮用水中给药4周。17周龄时处死大鼠。根据组织病理学检查诊断为骨坏死。通过免疫染色评估氧化应激。 普伐他汀组的组织学骨坏死发生率较低。骨髓中脂肪细胞面积百分比PS组低于S组。氧化应激的免疫组织化学染色显示，染色少，在PS组比S组。普伐他汀对血脂代谢的血液生化结果没有影响。然而，它降低了这些SHRSP大鼠中类固醇诱导的ONFH的发生率。我们推测这是通过减少氧化应激和减少股骨头中脂肪细胞面积的百分比而发生的。 我们的数据表明，普伐他汀可能是有效的减少类固醇诱导的ONFH。
Although the definite cause of steroid-induced osteonecrosis of the femoral head (ONFH) is unknown, peripheral circulatory failure, lipid metabolism disturbance, and increased oxidative stress are considered to be possible causes. We investigated whether pravastatin as a statin treatment reduces (1) the incidence of ONFH, (2) the adipocyte area, and (3) bone marrow changes in the femoral head. We divided up 81 thirteen-week-old spontaneously hypertensive stroke-prone (SHRSP)/Izm male rats into 4 groups: a control group (group C), a group given pravastatin (group P), a group given steroid (group S), and a group given both pravastatin and steroid (Group PS). The steroid was administered at 15 weeks of age. Pravastatin, as a statin, was administered in the drinking water for 4 weeks. The rats were killed when 17 weeks old. Osteonecrosis was diagnosed based on histopathological examination. Oxidative stress was assessed from immunostaining. The incidence of histological osteonecrosis was lower in the groups given pravastatin. The percentage of adipocyte area in the bone marrow was lower in the PS group than in the S group. Immunohistochemical staining for oxidative stress showed that staining was less in the PS group than in the S group. Pravastatin had no effect on the blood-derived biochemical findings on lipid metabolism. However, it reduced the incidence of steroid-induced ONFH in these SHRSP rats. We presume that this occurred by reducing oxidative stress and by reducing the percentage of adipocyte area in the femoral heads. Our data suggest that pravastatin may be effective in reducing steroid-induced ONFH.
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