A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75.
A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75.
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DOI：
10.1016/j.celrep.2022.111903
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发表时间：
2023-01-31
期刊：
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
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作者：
严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）的变异体已经引起了连续的全球感染浪潮。这些在刺突蛋白中具有多个突变的变体被认为有助于逃避天然和疫苗诱导的免疫，并且通常增加对ACE 2的亲和力。最新引起关注的变种是BA.2.75，在印度被发现，它现在是印度的主要菌株，有证据表明它的传播范围更广。BA.2.75衍生自BA.2，在受体结合结构域（RBD）中含有四个额外的突变。在这里，我们进行抗原和生物物理特性的BA.2.75，揭示了体液逃避和ACE 2受体亲和力之间的一个有趣的平衡。与BA.2相比，ACE 2对BA.2.75的亲和力增加了9倍;也有证据表明BA.2.75从免疫血清中逃逸，特别是由Delta感染诱导的免疫血清，这可以解释在印度的快速传播，在那里有高的Delta感染背景。ACE 2亲和力似乎优先于更大的逃逸。Huo等人描述SARS-CoV-2变异体BA.2.75（最初在印度发现）的特征。其对ACE 2的亲和力比BA.2增加9倍，并且有证据表明BA.2.75从免疫血清中逃逸，特别是从Delta感染中逃逸。ACE 2亲和力似乎优先于通过R493 Q回复突变的更大逃逸。
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have caused successive global waves of infection. These variants, with multiple mutations in the spike protein, are thought to facilitate escape from natural and vaccine-induced immunity and often increase in affinity for ACE2. The latest variant to cause concern is BA.2.75, identified in India where it is now the dominant strain, with evidence of wider dissemination. BA.2.75 is derived from BA.2 and contains four additional mutations in the receptor-binding domain (RBD). Here, we perform an antigenic and biophysical characterization of BA.2.75, revealing an interesting balance between humoral evasion and ACE2 receptor affinity. ACE2 affinity for BA.2.75 is increased 9-fold compared with BA.2; there is also evidence of escape of BA.2.75 from immune serum, particularly that induced by Delta infection, which may explain the rapid spread in India, where where there is a high background of Delta infection. ACE2 affinity appears to be prioritized over greater escape. Huo et al. characterize the SARS-CoV-2 variant BA.2.75 (originally identified in India). Its affinity for ACE2 is increased 9-fold over BA.2, and there is evidence of escape of BA.2.75 from immune serum, particularly from Delta infection. ACE2 affinity appears to be prioritized over greater escape via the R493Q reversion mutation.
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影响因子：
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作者：
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作者：
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通讯作者：
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影响因子：
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