Hippocampal neurogenesis levels predict WATERMAZE search strategies in the aging brain.
Hippocampal neurogenesis levels predict WATERMAZE search strategies in the aging brain.
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DOI：
10.1371/journal.pone.0075125
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Christie BR
中科院分区：
文献类型：
--
作者：
Gil-Mohapel J;Brocardo PS;Choquette W;Gothard R;Simpson JM;Christie BR
海马体在空间记忆的形成中起着至关重要的作用，人们认为成人海马体神经发生可能参与了这种形式的学习。为了更好地阐明神经发生和空间学习之间的关系，我们在小鼠的整个生命周期中对两者进行了研究。我们发现，随着年龄的增长，细胞增殖、神经元分化和神经发生显著减少，并且在1.5-3个月大的早期，这些过程突然减少。在此之后，神经发生能力继续稳步下降。成人神经发生的最初突然下降与莫里斯水迷宫表现的显著下降平行，但此后整体学习和记忆保持不变。对所采用的搜索策略的进一步分析表明，衰老大脑中神经发生的减少与采用空间不精确的搜索策略密切相关。总体而言，由于空间不精确搜索策略的使用增加，莫里斯水迷宫中老龄动物的学习和记忆性能指标保持在相对恒定的水平。
The hippocampus plays a crucial role in the formation of spatial memories, and it is thought that adult hippocampal neurogenesis may participate in this form of learning. To better elucidate the relationship between neurogenesis and spatial learning, we examined both across the entire life span of mice. We found that cell proliferation, neuronal differentiation, and neurogenesis significantly decrease with age, and that there is an abrupt reduction in these processes early on, between 1.5-3 months of age. After this, the neurogenic capacity continues to decline steadily. The initial abrupt decline in adult neurogenesis was paralleled by a significant reduction in Morris Water Maze performance, however overall learning and memory remained constant thereafter. Further analysis of the search strategies employed revealed that reductions in neurogenesis in the aging brain were strongly correlated with the adoption of spatially imprecise search strategies. Overall, performance measures of learning and memory in the Morris Water Maze were maintained at relatively constant levels in aging animals due to an increase in the use of spatially imprecise search strategies.
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