The effects of aging on stem cell behavior in Drosophila.
The effects of aging on stem cell behavior in Drosophila.
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DOI：
10.1016/j.exger.2010.10.005
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发表时间：
2011-05
影响因子：
3.9
通讯作者：
Jones, D. Leanne
中科院分区：
文献类型：
--
作者：
Wang, Lei;Jones, D. Leanne
在整个生命过程中，成体干细胞通过提供用于体内平衡和再生的细胞库在维持组织和器官功能方面发挥重要作用。因此，干细胞数量或活性的下降可能导致器官和组织功能受损，这是衰老的特征。果蝇已经成为研究干细胞与衰老之间关系的理想系统，因为它的寿命很短，组织由成体干细胞维持，并且已知调节衰老的保守途径。在这篇综述中，我们强调了最近的研究结果，描述内在和外在的年龄相关的变化，影响果蝇生殖细胞和肠道干细胞的行为。我们还讨论了影响寿命的途径是否可以在衰老过程中自主或非自主地在干细胞中发挥作用。
Throughout life, adult stem cells play essential roles in maintaining tissue and organ function by providing a reservoir of cells for homeostasis and regeneration. A decline in stem cell number or activity may, therefore, lead to compromised organ and tissue function that is characteristic of aging. Drosophila has emerged as an ideal system for studying the relationship between stem cells and aging, as it has a short lifespan, tissues that are maintained by adult stem cells, and conserved pathways known to regulate aging. In this review, we highlight recent findings describing intrinsic and extrinsic age-related changes that affect the behavior of Drosophila germline and intestinal stem cells. We also discuss whether pathways affecting lifespan can act autonomously or non-autonomously in stem cells during aging.
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影响因子：
4.5
作者：
Biteau B;Karpac J;Supoyo S;Degennaro M;Lehmann R;Jasper H
通讯作者：
Jasper H
影响因子：
7.8
作者：
Mair W;McLeod CJ;Wang L;Jones DL
通讯作者：
Jones DL
DOI：
10.1073/pnas.0809144106
发表时间：
2009-01-27
影响因子：
11.1
作者：
Hsu, Hwei-Jan;Drummond-Barbosa, Daniela
通讯作者：
Drummond-Barbosa, Daniela
影响因子：
9.2
作者：
McLeod, Catherine J.;Wang, Lei;Wong, Chihunt;Jones, D. Leanne
通讯作者：
Jones, D. Leanne
影响因子：
29
作者：
Jasper H;Jones DL
通讯作者：
Jones DL