Serum Mac-2 binding protein level predicts the development of liver-related events and colorectal cancer in patients with NAFLD.
Serum Mac-2 binding protein level predicts the development of liver-related events and colorectal cancer in patients with NAFLD.
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DOI：
10.1002/hep4.1934
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发表时间：
2022-07
影响因子：
5.1
通讯作者：
中科院分区：
文献类型：
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我们先前证明Mac-2结合蛋白（M2 BP）是非酒精性脂肪肝（NAFLD）的有用生物标志物，特别是NAFLD纤维化预测。在本研究中，我们调查了M2 BP在NAFLD患者中的预后价值。2002年至2013年，共有506例经活检证实的NAFLD患者入组本研究。这些NAFLD患者中有353例可接受超过100天的随访，并且在入组时未显示肝脏相关事件。肝脏相关事件定义为肝细胞癌（HCC）、失代偿和胃食管静脉曲张伴静脉曲张治疗。所有受试者的平均随访时间为2716 ± 1621天（102-7483天）。18例患者发生了新的肝脏相关事件（HCC，8例;失代偿，11例;静脉曲张，8例）。9名患者发生心血管疾病（CVD），24名患者在其他器官中发生新的癌症。中位血清M2 BP水平为1.603 μg/mL，我们根据血清M2 BP水平将我们的队列分为两组：M2 BP低组（M2 BP低）和M2 BP高组（M2 BP高）。M2 BP Hi组（n = 8）的HCC发生率显著高于M2 BP Low组（n = 0）。M2 BP高组（n = 16）的肝脏相关事件发生率显著高于M2 BP低组（n = 2）。死亡、CVD事件和其他器官癌症的发生率在两组之间没有差异。有趣的是，结直肠癌的发病率在M2 BP Hi（n = 5）中显著高于M2 BP Low（n = 0）。结论：M2 BP是预测肝脏相关事件，特别是HCC的有用生物标志物。此外，M2 BP是结直肠癌发展的潜在预测生物标志物。我们先前证明Mac-2结合蛋白（M2 BP）是非酒精性脂肪肝（NAFLD）的有用生物标志物，特别是NAFLD纤维化预测。在这项研究中，我们发现M2 BP是预测肝脏相关事件，特别是HCC的有用生物标志物。此外，M2 BP是结直肠癌发展的潜在预测生物标志物。
We previously demonstrated that Mac‐2 binding protein (M2BP) is a useful biomarker for nonalcoholic fatty liver disease (NAFLD), particularly NAFLD fibrosis prediction. In the present study, we investigated the prognostic value of M2BP in patients with NAFLD. A total of 506 patients with biopsy‐confirmed NAFLD from 2002 to 2013 were enrolled in this study in Japan. Three hundred fifty‐three of these patients with NAFLD were available for follow‐up for more than 100 days and showed no liver‐related events at the time of entry. Liver‐related events were defined as hepatocellular carcinoma (HCC), decompensation, and gastroesophageal varices with variceal treatment. The mean follow‐up duration of all the subjects was 2716 ± 1621 days (102–7483 days). Eighteen patients developed new liver‐related events (HCC, 8; decompensation, 11; varices, 8). Nine patients developed cardiovascular disease (CVD), and 24 patients developed new cancers in other organs. The median serum M2BP level was 1.603 μg/mL, and we divided our cohort into two groups according to the serum M2BP level: M2BP low group (M2BP Low) and M2BP high group (M2BP Hi). The incidence of HCC was significantly higher in M2BP Hi (n = 8) than in M2BP Low (n = 0). The incidence of liver‐related events was significantly higher in M2BP Hi (n = 16) than in M2BP Low (n = 2). The incidences of death, CVD events, and cancer in other organs were not different between the groups. Interestingly, the incidence of colorectal cancer was significantly higher in M2BP Hi (n = 5) than in M2BP Low (n = 0). Conclusion: M2BP is a useful biomarker to predict liver‐related events, particularly HCC. Additionally, M2BP is a potential predictive biomarker of colorectal cancer development. We previously demonstrated that Mac‐2 binding protein (M2BP) is a useful biomarker for nonalcoholic fatty liver disease (NAFLD), particularly NAFLD fibrosis prediction. In this study we found that M2BP is a useful biomarker to predict liver‐related events, particularly HCC. Additionally, M2BP is a potential predictive biomarker of colorectal cancer development.
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影响因子：
2.5
作者：
Cheung, K. J.;Tilleman, K.;Van Vlierberghe, H.
通讯作者：
Van Vlierberghe, H.
影响因子：
3
作者：
Grassadonia, A;Tinari, N;Iacobelli, S
通讯作者：
Iacobelli, S
影响因子：
29.4
作者：
Angulo P;Kleiner DE;Dam-Larsen S;Adams LA;Bjornsson ES;Charatcharoenwitthaya P;Mills PR;Keach JC;Lafferty HD;Stahler A;Haflidadottir S;Bendtsen F
通讯作者：
Bendtsen F
影响因子：
29.4
作者：
Matteoni, CA;Younossi, ZM;McCullough, AJ
通讯作者：
McCullough, AJ
影响因子：
158.5
作者：
Mazzaferro, V;Regalia, E;Gennari, L
通讯作者：
Gennari, L