Interactions between corticotropin-releasing factor and the serotonin 1A receptor system on acoustic startle amplitude and prepulse inhibition of the startle response in two rat strains.
Interactions between corticotropin-releasing factor and the serotonin 1A receptor system on acoustic startle amplitude and prepulse inhibition of the startle response in two rat strains.
复制标题
在声学惊悚幅度上，皮质激素释放因子与5-羟色胺1A受体系统之间的相互作用与两种大鼠菌株中惊吓反应的预硫化作用。
DOI：
10.1016/j.neuropharm.2011.07.016
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发表时间：
2012-01
影响因子：
4.7
通讯作者：
Conti LH
中科院分区：
文献类型：
--
作者：
Conti LH
Both the neuropeptide, corticotropin-releasing factor (CRF) and the serotonin 1A (5-HT1A) receptor systems have been implicated in anxiety disorders and there is evidence that the two systems interact with each other to affect behavior. Both systems have individually been shown to affect prepulse inhibition (PPI) of the acoustic startle response. PPI is a form of sensorimotor gating that is reduced in patients with anxiety disorders including post-traumatic stress and panic disorder. Here, we examined whether the two systems interact or counteract each other to affect acoustic startle amplitude, PPI and habituation of the startle response. In experiment 1, Brown Norway (BN) and Wistar-Kyoto (WKY) rats were administered ether an intraperitoneal (IP) injection of saline or the 5-HT1A receptor agonist, 8-OH-DPAT 10 min prior to receiving an intracerebroventricular (ICV) infusion of either saline or CRF (0.3 µg). In a second experiment, rats were administered either an IP injection of saline or the 5-HT1A receptor antagonist, WAY 100,635 10 min prior to receiving an ICV infusion of saline or CRF. Thirty min after the ICV infusion, the startle response and PPI were assessed. As we have previously shown, the dose of CRF used in these experiments reduced PPI in BN rats and had no effect on PPI in WKY rats. Administration of 8-OH-DPAT alone had no effect on PPI in either rat strain when the data from the two strains were examined separately. Administration of 8-OHDPAT added to the effect of CRF in BN rats, and the combination of 8-OH-DPAT and CRF significantly reduced PPI in WKY rats. CRF alone had no effect on baseline startle amplitude in either rat strain, but CRF enhanced the 8-OH-DPAT-induced increase in startle in both strains. Administration of WAY 100,635 did not affect the CRF-induced change in PPI and there were no interactions between CRF and WAY 100,635 on baseline startle. The results suggest that activation of the 5-HT1A receptor can potentiate the effect of CRF on endophenotypes of anxiety disorders in animal models.
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影响因子：
16.2
作者：
CHANG, CP;PEARSE, RV;ROSENFELD, MG
通讯作者：
ROSENFELD, MG
影响因子：
7.6
作者：
Dulawa, SC;Gross, C;Geyer, MA
通讯作者：
Geyer, MA
影响因子：
5
作者：
Conti, LH
通讯作者：
Conti, LH
影响因子：
7.6
作者：
Breese, GR;Knapp, DJ;Overstreet, DH
通讯作者：
Overstreet, DH
影响因子：
4.7
作者：
Bubenikova-Valesova, Vera;Votava, Martin;Horacek, Jiri
通讯作者：
Horacek, Jiri