Neuronal circuitry underlying the impact of D3 receptor ligands in drug addiction.
Neuronal circuitry underlying the impact of D3 receptor ligands in drug addiction.
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DOI：
10.1016/j.euroneuro.2014.08.017
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发表时间：
2015-09
影响因子：
5.6
通讯作者：
Di Ciano, Patricia
中科院分区：
文献类型：
--
作者：
Le Foll, Bernard;Di Ciano, Patricia
自20世纪90年代初克隆D3受体以来，人们对这种受体作为药物成瘾的可能治疗靶点产生了极大的兴趣。适合人类使用的D3配体的开发仍然难以捉摸，因此对D3受体功能及其可能的治疗效果的研究在很大程度上仅限于动物。临床前研究已经证实，全身给药D3配体，特别是拮抗剂和部分激动剂，可以改变动物的药物寻找。尽管经过十多年的研究，很少有研究调查脑内灌注D3配体对药物寻找的影响。在本综述中，我们总结了这些主要集中在刺激控制行为的研究。来自D3受体表达、Fos和phMRI研究的证据也提供了描述一些D3脑系统参与药物寻找和服用的证据。迄今为止的数据表明，不同的大脑系统可能参与不同类型的刺激控制以及药物服用。
Since the cloning of the D3 receptor in the early 1990s, there has been a great deal of interest in this receptor as a possible therapeutic target for drug addiction. The development of a D3 ligand suitable for use in humans has remained elusive, so the study of the function of the D3 receptor and its possible therapeutic efficacy has largely been restricted to animals. Pre-clinical studies have established that systemic administration of D3 ligands, particularly antagonists and partial agonists, can alter drug-seeking in animals. Despite over a decade of research, few studies have investigated the effects of intra-cerebral infusion of D3 ligands on drug-seeking. In the present review, we summarize these studies, which have largely focused on stimulus-controlled behaviors. Converging evidence from studies of D3 receptor expression, Fos and phMRI is also provided to delineate some of the D3 brain systems involved in drug-seeking and taking. The data so far indicate that different brain systems may be involved in different types of stimulus control as well as drug taking.
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影响因子：
7.6
作者：
Di Ciano, P;Underwood, RJ;Everitt, BJ
通讯作者：
Everitt, BJ
影响因子：
3.4
作者：
Di Ciano, P;Blaha, CD;Phillips, AG
通讯作者：
Phillips, AG
影响因子：
3.4
作者：
Di Ciano, P;Blaha, CD;Phillips, AG
通讯作者：
Phillips, AG
影响因子：
7.6
作者：
Andreoli, M;Tessari, M;Heidbreder, CA
通讯作者：
Heidbreder, CA
DOI：
10.1124/jpet.110.167619
发表时间：
2010-08-10
影响因子：
3.5
作者：
Achat-Mendes, Cindy;Grundt, Peter;Spealman, Roger D.
通讯作者：
Spealman, Roger D.