Spatial Regulation Control of Oxygen Metabolic Consumption in Mouse Brain.
Spatial Regulation Control of Oxygen Metabolic Consumption in Mouse Brain.
复制标题
小鼠脑氧代谢消耗的空间调节控制
DOI：
10.1002/advs.202204468
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发表时间：
2022-12
期刊：
影响因子：
15.1
通讯作者：
Su, Bin
中科院分区：
文献类型：
--
作者：
Zhou, Lin;Li, Xinru;Su, Bin
关键词：
哺乳动物的大脑依赖于大量的氧代谢消耗来实现能量供应、大脑功能和神经活动。在这项研究中，在体内电化学与生理和行为学分析相结合，探讨在小鼠大脑的一个区域，包括部分的初级体感皮层，初级运动皮层，海马和纹状体的氧代谢消耗。通过使用巧妙设计的抗生物污染碳纤维微电极测量体内电流，可以在空间上分辨该边界部分不同位置的氧气水平。通过同时记录小鼠的生理反应来进一步解释电流信号的特征。此外，进行行为学测试以验证氧水平和小鼠行为之间的相关性。研究发现，高剂量咖啡因注射可以引起四个相邻脑区之间氧代谢消耗的空间变异性。提出不同脑区的氧代谢消耗不是相互独立的，而是遵循“脑区等级”和“相对距离”规则进行空间调控的。此外，正如体内无线电化学和行为学分析所揭示的那样，小鼠长期摄入高剂量咖啡因有神经元损伤的风险。
The mammalian brain relies on significant oxygen metabolic consumption to fulfill energy supply, brain function, and neural activity. In this study, in vivo electrochemistry is combined with physiological and ethological analyses to explore oxygen metabolic consumption in an area of the mouse brain that includes parts of the primary somatosensory cortex, primary motor cortex, hippocampus, and striatum. The oxygen levels at different locations of this boundary section are spatially resolved by measuring the electrical current in vivo using ingeniously designed anti‐biofouling carbon fiber microelectrodes. The characteristics of the current signals are further interpreted by simultaneously recording the physiological responses of the mice. Additionally, ethological tests are performed to validate the correlation between oxygen levels and mouse behavior. It is found that high‐dose caffeine injection can evoke spatial variability in oxygen metabolic consumption between the four neighboring brain regions. It is proposed that the oxygen metabolic consumption in different brain regions is not independent of each other but is subject to spatial regulation control following the rules of “rank of brain region” and “relative distance.” Furthermore, as revealed by in vivo wireless electrochemistry and ethological analysis, mice are at risk of neuronal damage from long‐term intake of high‐dose caffeine.
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