Prospective associations of B-type natriuretic peptide with markers of left ventricular function in individuals with and without type 2 diabetes: an 8-year follow-up of the Hoorn Study.
Prospective associations of B-type natriuretic peptide with markers of left ventricular function in individuals with and without type 2 diabetes: an 8-year follow-up of the Hoorn Study.
复制标题
DOI：
10.2337/dc11-1959
复制
发表时间：
2012-12
期刊：
影响因子：
16.2
通讯作者：
Dekker JM
中科院分区：
文献类型：
--
作者：
Kroon MH;van den Hurk K;Alssema M;Kamp O;Stehouwer CD;Henry RM;Diamant M;Boomsma F;Nijpels G;Paulus WJ;Dekker JM
心力衰竭在2型糖尿病患者中很常见，早期发现有风险的个体可能会提供预防的机会。我们的目的是探讨1）在非心力衰竭范围内B型利钠肽（BNP）水平与左心室（LV）功能标志物变化的前瞻性相关性，以及2）在基于人群的队列中2型糖尿病可能的效应改变。在基线（2000-2001年）和随访（2007-2009年）时进行超声心动图测量，同时对纵向Hoorn研究的300名个体（平均年龄66岁，32%患有2型糖尿病）进行标准化体格检查和BNP测量。进行多变量线性回归分析，以研究基线BNP（<100 pg/mL）与LV质量指数、LV射血分数、左房容积指数和舒张早期LV流入速度（E）与舒张早期延长速度（e′）比值（E/e′）变化之间的关系。在所有个体中，BNP升高与8年左心房容积指数增加相关。BNP升高还与左室质量指数和E/e′增加相关。这些关联在2型糖尿病患者中显著强于无2型糖尿病患者中的非显著关联。这项为期8年的随访研究表明，在非心力衰竭范围内，BNP水平较高与LV质量增加和LV舒张功能恶化相关，特别是在2型糖尿病患者中。这意味着，如果使用BNP水平评估未来心力衰竭风险，则应考虑是否存在2型糖尿病。
Heart failure is common in individuals with type 2 diabetes, and early detection of individuals at risk may offer opportunities for prevention. We aimed to explore 1) prospective associations of B-type natriuretic peptide (BNP) levels in a non–heart failure range with changes in markers of left ventricular (LV) function and 2) possible effect modification by type 2 diabetes in a population-based cohort. Echocardiographic measurements were performed at baseline (2000–2001) and follow-up (2007–2009), together with standardized physical examinations and BNP measurements on 300 individuals (mean age 66 years, 32% with type 2 diabetes) of the longitudinal Hoorn Study. Multivariate linear regression analyses were performed to investigate associations of baseline BNP (<100 pg/mL) in individuals without prevalent heart failure at baseline with changes in LV mass index, LV ejection fraction, left atrial volume index, and ratio of early diastolic LV inflow velocity (E) to early diastolic lengthening velocity (e′) (E/e′). In all individuals, higher BNP was associated with 8-year increases in left atrial volume index. Higher BNP was also associated with increasing LV mass index and E/e′. These associations were significantly stronger in individuals with type 2 diabetes compared with the nonsignificant associations in individuals without type 2 diabetes. This 8-year follow-up study shows that higher BNP levels in a non–heart failure range were associated with an increased LV mass and deteriorated LV diastolic function, particularly in individuals with type 2 diabetes. This implies that the presence or absence of type 2 diabetes should be taken into account if BNP levels are used to assess future heart failure risk.
登录
查看更多内容
影响因子：
39.3
作者：
Goetze, Jens Peter;Mogelvang, Rasmus;Jensen, Jan Skov
通讯作者：
Jensen, Jan Skov
影响因子：
37.8
作者：
Das, SR;Drazner, MH;de Lemos, JA
通讯作者：
de Lemos, JA
影响因子：
18.2
作者：
van den Hurk, Katja;Alssema, Marjan;Dekker, Jacqueline M.
通讯作者：
Dekker, Jacqueline M.
影响因子：
120.7
作者：
Kistorp, C;Raymond, I;Hildebrandt, P
通讯作者：
Hildebrandt, P
影响因子：
158.5
作者：
Wang, TJ;Larson, MG;Vasan, RS
通讯作者：
Vasan, RS