Neonatal Cutaneous Invasive Aspergillosis Accompanied by Hemophagocytic Lymphohistocytosis.

Neonatal Cutaneous Invasive Aspergillosis Accompanied by Hemophagocytic Lymphohistocytosis.
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新生儿皮肤侵袭性曲霉病伴有噬血细胞性淋巴组织细胞增多症。

DOI:
10.1097/inf.0000000000001463
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发表时间:
2017-04
影响因子:
3.6
通讯作者:
Feng Peiying
Feng Peiying
中科院分区:
医学4区
文献类型:
--
作者:
Chen Zhuanggui;Yang Lifen;Li Yating;Pan Li;Li Meirong;Al-Hatmi Abdullah M S;Meis Jacques F;Lai Wei;Feng Peiying

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我们报告一个六周大的女婴,患有皮肤侵袭性曲霉菌病,并伴有噬血细胞淋巴组织细胞增生症。从前额和头皮坏死性皮肤病变的活检组织中分离出黄曲霉菌;通过分子分析证实了形态学鉴定。体外抗真菌药敏试验结果表明,三唑类化合物和阿朴霉素B具有较强的抗真菌活性。患者对静脉注射阿替霉素B联合口服泊沙康唑和局部伤口护理治疗反应良好。皮肤曲霉病治疗后噬血细胞淋巴组织细胞增多症减轻。皮肤侵袭性曲霉菌病和噬血细胞性淋巴组织细胞增生症都是严重的疾病,发病率和死亡率高,需要及时诊断和治疗。
We describe a 6-week-old female infant with cutaneous invasive aspergillosis accompanied with hemophagocytic lymphohistocytosis. Aspergillus flavus was isolated from biopsies of necrotic skin lesions on the forehead and scalp; morphologic identification was confirmed by molecular analysis. In vitro antifungal susceptibility testing showed that amphotericin B and triazoles had potent activity. The patient responded well to treatment with intravenous amphotericin B combined with oral posaconazole and local wound care. The hemophagocytic lymphohistocytosis abated after treatment of cutaneous aspergillosis. Both cutaneous invasive aspergillosis and hemophagocytic lymphohistocytosis are severe disorders with high morbidity and mortality requiring prompt diagnosis and treatment.
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发表时间: 2013-05
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