Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysis.
Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysis.
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严重手足口病的结局：系统评价和荟萃分析
DOI：
10.1016/j.ejpn.2018.04.007
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Sabanathan S
中科院分区：
文献类型：
--
作者：
Jones E;Pillay TD;Liu F;Luo L;Bazo-Alvarez JC;Yuan C;Zhao S;Chen Q;Li Y;Liao Q;Yu H;Rogier van Doorn H;Sabanathan S
由肠道病毒 A71 (EV-A71) 引起的手足口病 (HFMD) 与儿童急性神经系统疾病有关。本研究旨在评估严重手足口病后长期后遗症和死亡的负担。这项系统回顾和荟萃分析汇集了来自包括 MEDLINE 和万方在内的英文和中文数据库中关于临床诊断的手足口病和/或实验室确诊的 EV-A71 暴发的所有报告，并在 1966 年 1 月 1 日至 2015 年 10 月 19 日之间发表了至少 7 天的随访。两位独立评审员对文献进行了评估。我们使用随机效应荟萃分析来估计神经系统后遗症或死亡的累积发生率。对研究的方法学和报告质量进行了评估。 PROSPERO 注册号：10.15124/CRD42015021981。该评价纳入了 43 项研究，初步分析纳入了 9 项研究的 599 名儿童。最大随访时死亡或神经系统后遗症的估计累积发生率为 19.8%（95% CI：10.2%、31.3%）。异质性 (Iˆ2) 为 88.57%，部分原因是数据收集年份和研究报告质量。 IIa 级急性疾病严重程度的发生率为 0.00% (0.00, 0.00)； IIb/III 级为 17.0% (7.9, 28.2)； 81.6% (65.1, 94.5) 为 IV 级 (p = 0.00) 疾病。神经系统受累的手足口病与长期神经系统后遗症的沉重负担有关。急性疾病严重程度的分级是结果的有力预测因素。这项研究的优点包括双语方法和临床适用性。未来的前瞻性和干预性研究必须使用严格的方法来评估幸存者的长期结果。这项研究没有具体的资助。请参阅下文了解研究人员资助。严重手足口病（HFMD）与中枢神经系统受累有关。严重的手足口病与神经系统后遗症的严重负担有关。患有更严重急性疾病的人出现后遗症的风险更高。未来的前瞻性和干预性研究应该评估长期结果。
Hand, foot and mouth disease (HFMD) caused by enterovirus A71 (EV-A71) is associated with acute neurological disease in children. This study aimed to estimate the burden of long-term sequelae and death following severe HFMD. This systematic review and meta-analysis pooled all reports from English and Chinese databases including MEDLINE and Wangfang on outbreaks of clinically diagnosed HFMD and/or laboratory-confirmed EV-A71 with at least 7 days' follow-up published between 1st January 1966 and 19th October 2015. Two independent reviewers assessed the literature. We used a random effects meta-analysis to estimate cumulative incidence of neurological sequelae or death. Studies were assessed for methodological and reporting quality. PROSPERO registration number: 10.15124/CRD42015021981. 43 studies were included in the review, and 599 children from 9 studies were included in the primary analysis. Estimated cumulative incidence of death or neurological sequelae at maximum follow up was 19.8% (95% CI:10.2%, 31.3%). Heterogeneity (Iˆ2) was 88.57%, partly accounted for by year of data collection and reporting quality of studies. Incidence by acute disease severity was 0.00% (0.00, 0.00) for grade IIa; 17.0% (7.9, 28.2) for grade IIb/III; 81.6% (65.1, 94.5) for grade IV (p = 0.00) disease. HFMD with neurological involvement is associated with a substantial burden of long-term neurological sequelae. Grade of acute disease severity was a strong predictor of outcome. Strengths of this study include its bilingual approach and clinical applicability. Future prospective and interventional studies must use rigorous methodology to assess long-term outcomes in survivors. There was no specific funding for this study. See below for researcher funding. Severe hand, foot and mouth disease (HFMD) is associated with CNS involvement. Severe HFMD is associated with a significant burden of neurological sequelae. Those with more severe acute disease are at higher risk of developing sequelae. Future prospective and interventional studies should assess long-term outcomes.
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DOI：
10.1016/s1684-1182(10)60016-3
发表时间：
2010-04-01
影响因子：
7.4
作者：
Chen, Shih-Perng;Huang, Yhu-Chering;Lin, Tzou-Yien
通讯作者：
Lin, Tzou-Yien
影响因子：
3.1
作者：
Chen, Feng;Li, Jianjun;Li, Yan
通讯作者：
Li, Yan
影响因子：
--
作者：
Fang, Yirong;Wang, Shuiping;Zhu, Bao-Ping
通讯作者：
Zhu, Bao-Ping
影响因子：
3.2
作者：
Chang, Luan-Yin;Lee, Chin-Yun;Huang, Li-Min
通讯作者：
Huang, Li-Min
影响因子：
120.7
作者：
Chang, LY;Tsao, KC;Lin, TY
通讯作者：
Lin, TY