Arc regulates a second-guessing cognitive bias during naturalistic foraging through effects on discrete behavior modules.
Arc regulates a second-guessing cognitive bias during naturalistic foraging through effects on discrete behavior modules.
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DOI：
10.1016/j.isci.2023.106761
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发表时间：
2023-05-19
期刊：
影响因子：
5.8
通讯作者：
Gregg, Christopher
中科院分区：
文献类型：
--
作者：
Ravens, Alicia;Stacher-Horndli, Cornelia N.;Emery, Jared;Steinwand, Susan;Shepherd, Jason D.;Gregg, Christopher
在动物身上觅食依赖于先天的决策启发式，在某些情况下，这可能会导致次优的认知偏差。这些偏见背后的机制还不是很清楚，但很可能涉及到强烈的遗传效应。为了探索这一点，我们使用自然主义的觅食范式对禁食的老鼠进行了研究，发现了一种天生的认知偏见，称为“事后猜测”。这包括反复调查以前空置的食物块，而不是消耗可用的食物，这阻碍了小鼠最大限度地增加进食利益。突触可塑性基因Arc被发现在这种偏见中发挥了作用，因为Arc缺陷小鼠没有表现出事后猜测和更多的食物消耗。此外，无监督机器学习对觅食的分解识别出受Arc影响的特定行为序列或“模块”。这些发现突出了决策过程中认知偏差的遗传基础，显示了行为模块和认知偏差之间的联系，并提供了对Arc在自然主义觅食中的行为学作用的洞察。二次猜测是觅食小鼠的一种经济上的非理性认知偏差突触可塑性基因Arc的丢失，特别影响二次猜测机器学习觅食的分解揭示了Arc控制的行为认知决策偏差、遗传因素和行为模块啮齿动物行为的联系；神经科学；行为神经科学；认知神经科学
Foraging in animals relies on innate decision-making heuristics that can result in suboptimal cognitive biases in some contexts. The mechanisms underlying these biases are not well understood, but likely involve strong genetic effects. To explore this, we studied fasted mice using a naturalistic foraging paradigm and discovered an innate cognitive bias called “second-guessing.” This involves repeatedly investigating an empty former food patch instead of consuming available food, which hinders the mice from maximizing feeding benefits. The synaptic plasticity gene Arc is revealed to play a role in this bias, as Arc-deficient mice did not exhibit second-guessing and consumed more food. In addition, unsupervised machine learning decompositions of foraging identified specific behavior sequences, or “modules”, that are affected by Arc. These findings highlight the genetic basis of cognitive biases in decision making, show links between behavior modules and cognitive bias, and provide insight into the ethological roles of Arc in naturalistic foraging. Second-guessing is an economically irrational cognitive bias in foraging mice Loss of the synaptic plasticity gene, Arc, specifically affects second-guessing Machine learning decompositions of foraging reveal Arc-controlled behaviors Linkage of cognitive decision bias, genetic factors, and behavioral modularity Rodent behavior; Neuroscience; Behavioral neuroscience; Cognitive neuroscience
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影响因子：
8.8
作者：
Homdli, Cornelia N. Stacher;Wong, Eleanor;Gregg, Christopher
通讯作者：
Gregg, Christopher
影响因子：
64.8
作者：
Daw, Nathaniel D.;O'Doherty, John P.;Dayan, Peter;Seymour, Ben;Dolan, Raymond J.
通讯作者：
Dolan, Raymond J.
DOI：
10.1073/pnas.1800795115
发表时间：
2018-06-05
影响因子：
11.1
作者：
Bang, Dan;Fleming, Stephen M.
通讯作者：
Fleming, Stephen M.
影响因子：
8.8
作者：
Bonthuis, Paul J.;Huang, Wei-Chao;Gregg, Christopher
通讯作者：
Gregg, Christopher
影响因子：
2.7
作者：
EILAM, D;GOLANI, I
通讯作者：
GOLANI, I