Anaplastic oligoastrocytoma: is molecular stratification based on 1p/19q status alone appropriate?
Anaplastic oligoastrocytoma: is molecular stratification based on 1p/19q status alone appropriate?
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间变性寡星形细胞瘤：仅基于 1p/19q 状态的分子分层是否合适？
DOI：
10.1007/s11060-014-1705-x
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发表时间：
2015-01
影响因子：
3.9
通讯作者：
Li Yang
中科院分区：
文献类型：
--
作者：
Yi Shu;Chao Mao;Bin Yan;Li Yang
我们感兴趣地阅读了Jiang等人最近发表的一篇关于基于1 p/19 q状态的高级别少突胶质细胞肿瘤（HGRP）的分子分类的论文。作者使用117例组织学诊断为原发性HIVER的肿瘤，将这些患者分为4种亚型，根据风险因素的数量（较高的肿瘤分级、1 p/19 q维持和1 q/19 p共体性），这些亚型具有显著不同的预后。作者得出结论，仅基于1 p/19 q状态的分子分类方案可以作为当前世界卫生组织分类系统的补充，并有助于个性化治疗决策。少突星形细胞瘤（OA）定义为具有类似少突胶质细胞和星形胶质细胞的两种不同肿瘤细胞类型的明显混合物的肿瘤。由于骨关节炎的组织学形态不均一，其诊断往往具有主观性。目前没有关于诊断所需的任何一部分的最低百分比的指南。因此，OA诊断的频率在不同机构之间变化很大，OA诊断的观察者间一致性很低，并且诊断在不同机构中的频率不同。可用于组织病理学诊断的材料通常数量有限，这进一步增加了诊断的不确定性。目前尚不清楚OA的少突胶质细胞和星形胶质细胞区域是否来自共同的细胞来源或在肿瘤转化过程中来自两个不同的细胞克隆。以前的研究表明，绝大多数的OAs，除了窝藏突变IDH 1/2，表现出纯少突胶质细胞瘤（1 p/19 q共缺失，CIC和FUBP 1突变）或星形细胞瘤（ATRX突变，p53突变）的分子特征，几乎完全相互排斥。这支持了OA作为一个独立的生物实体并不真正存在的观点。
We read with interest a recent paper published by Jiang et al. on molecular classification for high-grade oligodendroglial tumors (HGOs) based on 1p/19q status. Using 117 tumors with histological diagnosis of primary HGOs, the authors divided these patients into four subtypes which conferred remarkably distinct prognosis based on the number of risk factors (higher tumor grade, 1p/19q maintenance and 1q/19p copolysomy). The authors concluded that the molecular classification scheme based on 1p/19q status alone can serve as a supplement of the current WorldHealth Organization classification system and contribute to the personalized treatment decision-making. An oligoastrocytoma (OA) is defined as a tumor with a conspicuous mixture of two distinct neoplastic cell types resembling oligodendrocytes and astrocytes. Due to the heterogenous morphology, the histological diagnosis of OA is often subjective. No guidelines currently exist regarding the minimum percentage of either part required for the diagnosis. Consequently, the frequency of OA diagnosis varies widely among different institutions and the interobserver agreement of OA diagnosis is low and the diagnosis is made of varying frequencies in different institutions. The often limited amount of material available for histopathological diagnosis further contributes to the diagnostic uncertainty. It is still unclear if the oligodendroglial and astrocytic areas of OA are derived from a common cell origin or from two different cell clones during neoplastic transformation. Previous studies have shown that the vast majority of OAs, in addition to harboring mutations in IDH1/2, exhibit the molecular signature of either pure oligodendroglioma (1p/19q codeletion, CIC and FUBP1 mutation) or astrocytoma (ATRX mutation, p53 mutation) with almost complete mutual exclusivity. This supports the notion that OA, as an independent biological entity, does not truly exist.
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国际神经病理学协会 - 哈勒姆神经系统肿瘤分类和分级共识指南。
DOI：
10.1111/bpa.12171
发表时间：
2014-09
期刊：
Brain pathology (Zurich, Switzerland)
影响因子：
--
作者：
Louis DN;Perry A;Burger P;Ellison DW;Reifenberger G;von Deimling A;Aldape K;Brat D;Collins VP;Eberhart C;Figarella-Branger D;Fuller GN;Giangaspero F;Giannini C;Hawkins C;Kleihues P;Korshunov A;Kros JM;Beatriz Lopes M;Ng HK;Ohgaki H;Paulus W;Pietsch T;Rosenblum M;Rushing E;Soylemezoglu F;Wiestler O;Wesseling P;International Society Of Neuropathology--Haarlem
通讯作者：
International Society Of Neuropathology--Haarlem
影响因子：
12.7
作者：
Qu, Mingqi;Olofsson, Tommie;Ren, Zhi-Ping
通讯作者：
Ren, Zhi-Ping
影响因子：
12.7
作者：
Sahm, Felix;Reuss, David;von Deimling, Andreas
通讯作者：
von Deimling, Andreas
DOI：
10.1097/00005072-199501000-00011
发表时间：
1995-01-01
影响因子：
3.2
作者：
KRAUS, JA;KOOPMANN, J;VONDEIMLING, A
通讯作者：
VONDEIMLING, A