Skeleton and glucose metabolism: a bone-pancreas loop.

Skeleton and glucose metabolism: a bone-pancreas loop.
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DOI:
10.1155/2015/758148
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发表时间:
2015
影响因子:
2.8
通讯作者:
Brunetti G
Brunetti G
中科院分区:
医学4区
文献类型:
--
作者:
Faienza MF;Luce V;Ventura A;Colaianni G;Colucci S;Cavallo L;Grano M;Brunetti G

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骨被认为是运动、钙稳态和造血功能所必需的结构。骨生物学的最新进展突出了骨骼作为内分泌器官的重要性,其调节一些代谢途径,特别是胰岛素信号传导和葡萄糖耐量。这篇综述将指出骨作为内分泌“腺体”的作用,特别是骨特异性蛋白质,如骨钙素(OCN)和参与骨重塑的蛋白质,如骨保护素,在胰岛素功能和葡萄糖代谢的调节中。
Bone has been considered a structure essential for mobility, calcium homeostasis, and hematopoietic function. Recent advances in bone biology have highlighted the importance of skeleton as an endocrine organ which regulates some metabolic pathways, in particular, insulin signaling and glucose tolerance. This review will point out the role of bone as an endocrine “gland” and, specifically, of bone-specific proteins, as the osteocalcin (Ocn), and proteins involved in bone remodeling, as osteoprotegerin, in the regulation of insulin function and glucose metabolism.
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