Skeleton and glucose metabolism: a bone-pancreas loop.
Skeleton and glucose metabolism: a bone-pancreas loop.
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DOI:
10.1155/2015/758148
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发表时间:
2015
影响因子:
2.8
通讯作者:
Brunetti G
中科院分区:
文献类型:
--
作者:
Faienza MF;Luce V;Ventura A;Colaianni G;Colucci S;Cavallo L;Grano M;Brunetti G
Bone has been considered a structure essential for mobility, calcium homeostasis, and hematopoietic function. Recent advances in bone biology have highlighted the importance of skeleton as an endocrine organ which regulates some metabolic pathways, in particular, insulin signaling and glucose tolerance. This review will point out the role of bone as an endocrine “gland” and, specifically, of bone-specific proteins, as the osteocalcin (Ocn), and proteins involved in bone remodeling, as osteoprotegerin, in the regulation of insulin function and glucose metabolism.
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