Evaluation of autologous serum skin test and skin prick test reactivity to house dust mite in patients with chronic spontaneous urticaria.
Evaluation of autologous serum skin test and skin prick test reactivity to house dust mite in patients with chronic spontaneous urticaria.
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DOI：
10.1371/journal.pone.0064142
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Hao F
中科院分区：
文献类型：
--
作者：
Song Z;Zhai Z;Zhong H;Zhou Z;Chen W;Hao F
慢性自发性荨麻疹（CSU）是一种常见的皮肤病，其病因尚不清楚。本研究对862例CSU患者进行了自体血清皮肤试验（ASST）和皮肤点刺试验（SPT）的屋尘螨（HDM）检出率进行了评价。还记录了临床特征、病程和治疗反应。ASST阳性率为46.3%，以30-39岁年龄组阳性率最高（52.1%）。153例HDM患者SPT阳性（17.7%）阳性率最高ASST阳性患者的荨麻疹活动性评分（UAS）较高，（4.18± 0.65vs3.67 ±0.53），但HDM阳性率较低（24.6%vs37.6%），与ASST阴性者比较（OR 1.84，95% CI 1.38-2.47）。根据ASST和SPT对HDM的结果，患者可分为4组，与其他亚组相比，ASST阳性和SPT阳性HDM患者的疾病活动性评分最高，血管性水肿发生率、疾病持续时间和每月需要的氯雷他定剂量更高（P<0.0001）。ASST阳性和/或SPT阳性的CSU患者比ASST阴性和/或SPT阴性的CSU患者病情活动性更强。根据SPT和ASST的结果可以进一步进行分类。
Chronic spontaneous urticaria (CSU) is a common skin disorder with etiology that is not well understood. In this study, we evaluated the prevalence of autologous serum skin test (ASST) and skin prick testing (SPT) to house dust mite (HDM) in 862 CSU cases in China. Clinical features, courses and treatment responses were also recorded. The prevalence of positive ASST was 46.3%, and patients aged 30–39 years had the highest positive rate (52.1%). Positive SPT to HDM was seen in 153 patients (17.7%) with the highest positive rate (34.2%) in patients aged 20 or less. Patients with positive ASST had higher urticaria activity scores (UAS) (4.18±0.65 vs. 3.67±0.53) but lower positive rates of HDM (24.6% vs. 37.6%), as compared with those with negative ASST (odds ratio (OR) 1.84, 95% CI 1.38–2.47). Patients could be categorized into four groups based on the results of ASST and SPT to HDM and patients with positive ASST and positive SPT to HDM had the highest disease activity scores, experienced higher frequencies of angioedema, diseases duration, and required higher dosage of loratadine every month, compared with other subgroups (P<0.0001). Patients with CSU showed varied responses of positive ASST and varied sensitivity to HDM, Patients with positive ASST and/or positive SPT had more disease activity compared with patients with negative ASST and/or negative SPT. Further classification can be made based on the result of SPT and ASST.
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影响因子：
12.4
作者：
Toubi, E;Kessel, A;Panasoff, J
通讯作者：
Panasoff, J
DOI：
10.1111/j.1610-0387.2008.06661.x
发表时间：
2008-04-01
影响因子：
3.6
作者：
Wedi, Bettina
通讯作者：
Wedi, Bettina
DOI：
10.4103/0378-6323.39691
发表时间：
2008-03-01
影响因子：
2.9
作者：
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通讯作者：
Dhar, Sandipan
影响因子：
2.8
作者：
Najib, Umer;Sheikh, Javed
通讯作者：
Sheikh, Javed
影响因子：
3.4
作者：
Staubach, P;Onnen, K;Kromminga, A
通讯作者：
Kromminga, A