Complement diagnostics: concepts, indications, and practical guidelines.
Complement diagnostics: concepts, indications, and practical guidelines.
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DOI：
10.1155/2012/962702
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发表时间：
2012
影响因子：
--
通讯作者：
Ekdahl KN
中科院分区：
文献类型：
--
作者：
Nilsson B;Ekdahl KN
补体系统中的异常已被证明是许多疾病和病理状况中的直接或间接病理生理机制，例如自身免疫性疾病、感染、癌症、同种异体和异种移植以及炎症。在前瞻性和回顾性研究中，对这些疾病进行了补体分析，发现患者组之间存在显著差异，但在许多疾病中，由于所使用的许多测定缺乏灵敏度和特异性，因此无法对个体患者进行预测。目前血清学诊断补体分析的基本适应症可分为三大类：（a）获得性和遗传性补体缺乏;（B）补体激活疾病;（c）遗传性和获得性C1 INH缺乏。在这里，我们总结了基本补体分析的适应症，技术和解释，并提出了一个算法，我们在我们的常规实验室遵循。
Aberrations in the complement system have been shown to be direct or indirect pathophysiological mechanisms in a number of diseases and pathological conditions such as autoimmune disease, infections, cancer, allogeneic and xenogeneic transplantation, and inflammation. Complement analyses have been performed on these conditions in both prospective and retrospective studies and significant differences have been found between groups of patients, but in many diseases, it has not been possible to make predictions for individual patients because of the lack of sensitivity and specificity of many of the assays used. The basic indications for serological diagnostic complement analysis today may be divided into three major categories: (a) acquired and inherited complement deficiencies; (b) disorders with complement activation; (c) inherited and acquired C1INH deficiencies. Here, we summarize indications, techniques, and interpretations for basic complement analyses and present an algorithm, which we follow in our routine laboratory.
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影响因子：
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通讯作者：
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