Dynamic control of decision and movement speed in the human basal ganglia.
Dynamic control of decision and movement speed in the human basal ganglia.
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DOI：
10.1038/s41467-022-35121-8
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发表时间：
2022-12-07
影响因子：
16.6
通讯作者：
Brown, Peter
中科院分区：
文献类型：
--
作者：
Herz, Damian M.;Bange, Manuel;Gonzalez-Escamilla, Gabriel;Auer, Miriam;Ashkan, Keyoumars;Fischer, Petra;Tan, Huiling;Bogacz, Rafal;Muthuraman, Muthuraman;Groppa, Sergiu;Brown, Peter
为了更好地调整我们的行为以适应不断变化的环境，我们需要调整我们的决策和行动的速度。然而，人们对这些过程在多大程度上是由共同的或单独的机制控制的知之甚少。此外，虽然以前的计算模型和实证研究的证据表明，基底神经节在调整决策过程中起着重要作用，但目前尚不清楚这是如何实现的。利用直接进入接受深部脑刺激手术的人类基底神经节的丘脑下核的机会，我们在这里结合了侵入性电生理记录、电刺激和感知决策的计算模型。我们证明，虽然丘脑下核对决策和运动速度的控制存在相似性，但丘脑下核对这些过程的因果贡献可以解开。我们的研究结果表明，在适应行为中，基底神经节独立地控制着每个半球的决策和运动速度。人类大脑中决定决策和运动速度的神经机制仍然知之甚少。在这里，作者揭示了丘脑下核独立控制每个半球的决策和运动速度。
To optimally adjust our behavior to changing environments we need to both adjust the speed of our decisions and movements. Yet little is known about the extent to which these processes are controlled by common or separate mechanisms. Furthermore, while previous evidence from computational models and empirical studies suggests that the basal ganglia play an important role during adjustments of decision-making, it remains unclear how this is implemented. Leveraging the opportunity to directly access the subthalamic nucleus of the basal ganglia in humans undergoing deep brain stimulation surgery, we here combine invasive electrophysiological recordings, electrical stimulation and computational modelling of perceptual decision-making. We demonstrate that, while similarities between subthalamic control of decision- and movement speed exist, the causal contribution of the subthalamic nucleus to these processes can be disentangled. Our results show that the basal ganglia independently control the speed of decisions and movement for each hemisphere during adaptive behavior. The neural mechanisms determining the speed of decisions and movements in the human brain remain poorly understood. Here, the authors reveal that the subthalamic nucleus causally controls decision and movement speed independently for each hemisphere.
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影响因子：
3.5
作者：
Barter, Joseph W.;Li, Suellen;Yin, Henry H.
通讯作者：
Yin, Henry H.
影响因子：
4.7
作者：
Devos, D.;Szurhaj, W.;Defebvre, L.
通讯作者：
Defebvre, L.
DOI：
10.1016/j.cub.2016.01.051
发表时间：
2016-04-04
期刊：
Current biology : CB
影响因子：
--
作者：
Herz DM;Zavala BA;Bogacz R;Brown P
通讯作者：
Brown P
影响因子：
5.7
作者：
Horn A;Li N;Dembek TA;Kappel A;Boulay C;Ewert S;Tietze A;Husch A;Perera T;Neumann WJ;Reisert M;Si H;Oostenveld R;Rorden C;Yeh FC;Fang Q;Herrington TM;Vorwerk J;Kühn AA
通讯作者：
Kühn AA
影响因子：
5.3
作者：
Bruecke, Christof;Huebl, Julius;Kuehn, Andrea A.
通讯作者：
Kuehn, Andrea A.