ACTN3 genotype, athletic status, and life course physical capability: meta-analysis of the published literature and findings from nine studies.
ACTN3 genotype, athletic status, and life course physical capability: meta-analysis of the published literature and findings from nine studies.
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DOI：
10.1002/humu.21526
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发表时间：
2011-09
期刊：
影响因子：
3.9
通讯作者：
Day, Ian N. M.
中科院分区：
文献类型：
--
作者：
Alfred, Tamuno;Ben-Shlomo, Yoav;Cooper, Rachel;Hardy, Rebecca;Cooper, Cyrus;Deary, Ian J.;Gunnell, David;Harris, Sarah E.;Kumari, Meena;Martin, Richard M.;Moran, Colin N.;Pitsiladis, Yannis P.;Ring, Susan M.;Sayer, Avan Aihie;Smith, George Davey;Starr, John M.;Kuh, Diana;Day, Ian N. M.
ACTN3 R577X (rs1815739) 基因型与运动状态和肌肉表型相关，但并非一致。我们的目标是对已发表的有关运动状态的文献进行荟萃分析，并在几项基于人群的新研究中调查其与身体能力的关联。相关数据是从文献研究中提取的，比较了对照组和短跑/力量和耐力运动员之间的基因型频率。对于生命全程身体能力，数据来自两项针对青少年的研究和七项跨生命历程健康老龄化 (HALCyon) 合作研究项目的研究，涉及年龄在 53 岁至 90 岁以上的个体。我们从已发表的文献中找到证据来支持这样的假设：在欧洲人中，与对照组相比，RR 基因型在短跑/力量运动员中更为常见。目前没有证据表明 X 等位基因有利于耐力运动能力。在我们的身体能力研究中，我们发现 R577X 与握力（男性 P = 0.09，n = 7,672；女性 P = 0.90，n = 7,839）、站立平衡、定时起身或起身之间没有关联。 ACTN3 R577X 基因型与欧洲人的短跑/力量运动状态相关，但似乎与一般人群身体能力的客观测量无关。 Hum Mutat 32:1–11, 2011。© 2011 Wiley-Liss, Inc.
The ACTN3 R577X (rs1815739) genotype has been associated with athletic status and muscle phenotypes, although not consistently. Our objective was to conduct a meta-analysis of the published literature on athletic status and investigate its associations with physical capability in several new population-based studies. Relevant data were extracted from studies in the literature, comparing genotype frequencies between controls and sprint/power and endurance athletes. For life course physical capability, data were used from two studies of adolescents and seven studies in the Healthy Ageing across the Life Course (HALCyon) collaborative research program, involving individuals aged between 53 and 90+ years. We found evidence from the published literature to support the hypothesis that in Europeans the RR genotype is more common among sprint/power athletes compared with their controls. There is currently no evidence that the X allele is advantageous to endurance athleticism. We found no association between R577X and grip strength (P = 0.09, n = 7,672 in males; P = 0.90, n = 7,839 in females), standing balance, timed get up and go, or chair rises in our studies of physical capability. The ACTN3 R577X genotype is associated with sprint/power athletic status in Europeans, but does not appear to be associated with objective measures of physical capability in the general population. Hum Mutat 32:1–11, 2011. © 2011 Wiley-Liss, Inc.
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