Theta oscillations in rat infralimbic cortex are associated with the inhibition of cocaine seeking during extinction.
Theta oscillations in rat infralimbic cortex are associated with the inhibition of cocaine seeking during extinction.
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DOI：
10.1111/adb.13106
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发表时间：
2022-01
影响因子：
3.4
通讯作者：
LaLumiere RT
中科院分区：
文献类型：
--
作者：
Müller Ewald VA;Kim J;Farley SJ;Freeman JH;LaLumiere RT
下缘皮质(IL)的操作表明，该区域调节灭绝学习，并抑制可卡因自我给药后寻求可卡因。然而，由于很难准确地确定在可卡因寻找过程中何时抑制寻找可卡因的行为，很少有工作记录到抑制寻找可卡因期间的IL活性。本研究使用体内电生理学来检测在可卡因自行给药和复吸期间的IL活性。Spraogue-Dawley大鼠接受了6小时的可卡因自我注射，其中反应杠杆在离散的信号试验中可用，这一过程允许比较寻求可卡因的时代和抑制可卡因的时代。随后，大鼠使用相同的程序进行了灭绝和可卡因诱导的恢复。结果表明，在所有实验阶段，Theta节律(4-10 GHz)主导着IL局部场电位(LFP)的活动。在灭绝过程中，杠杆按压周围的theta功率波动很大，当大鼠从事可卡因寻找时，theta力量比不寻求可卡因的大鼠低。这些振荡活动的模式不同于自我管理和恢复阶段。单单位分析表明IL单位反应的异质性，支持IL内存在多个神经元亚群的观点，并促进不同甚至相反的可卡因寻求行为的表达。总之，这些结果与以下观点是一致的，即IL中的突触和单位活动的聚集代表了IL参与行动监测，以促进与任务偶发事件相一致的适应行为，并揭示了IL活动与抑制可卡因寻求之间的关系的关键见解。在这项研究中，我们使用一种新的可卡因自我给药范式来比较寻找可卡因和抑制可卡因期间的下缘皮质(IL)活性。只有在灭绝训练期间，杠杆-按压事件周围的theta振荡才会发生变化，而在寻求可卡因的时期，theta的能力比抑制可卡因的时期要低。与单个单位和穗场结果一起，这些数据表明IL活性的作用超越了行为抑制，并可能有助于促进与任务偶发情况相一致的适应行为。
Infralimbic cortical (IL) manipulations indicate that this region mediates extinction learning and suppresses cocaine seeking following cocaine self‐administration. However, little work has recorded IL activity during the inhibition of cocaine seeking due to the difficulty of determining precisely when cocaine‐seeking behaviour is inhibited within a cocaine‐seeking session. The present study used in vivo electrophysiology to examine IL activity across extinction as well as during cocaine self‐administration and reinstatement. Sprague–Dawley rats underwent 6‐h access cocaine self‐administration in which the response lever was available during discrete signalled trials, a procedure which allowed for the comparison between epochs of cocaine seeking versus the inhibition thereof. Subsequently, rats underwent extinction and cocaine‐primed reinstatement using the same procedure. Results indicate that theta rhythms (4–10 Hz) dominated IL local‐field potential (LFP) activity during all experimental stages. During extinction, theta power fluctuated significantly surrounding the lever press and was lower when rats engaged in cocaine seeking versus when they withheld from doing so. These patterns of oscillatory activity differed from self‐administration and reinstatement stages. Single‐unit analyses indicate heterogeneity of IL unit responses, supporting the idea that multiple neuronal subpopulations exist within the IL and promote the expression of different and even opposing cocaine‐seeking behaviours. Together, these results are consistent with the idea that aggregate synaptic and single‐unit activity in the IL represent the engagement of the IL in action monitoring to promote adaptive behaviour in accordance with task contingencies and reveal critical insights into the relationship between IL activity and the inhibition of cocaine seeking. In this study, we use a novel cocaine self‐administration paradigm to compare infralimbic cortical (IL) activity during periods of cocaine seeking versus inhibition thereof. Only during extinction training theta oscillations varied surrounding the lever‐press event and theta power was lower during epochs of cocaine seeking versus the inhibition thereof. Together with single‐unit and spike‐field results, these data indicate a role for IL activity that goes beyond behavioural inhibition and may serve to promote adaptive behaviour in accordance with task contingencies.
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影响因子：
2.5
作者：
LEGENDY, CR;SALCMAN, M
通讯作者：
SALCMAN, M
影响因子：
5.3
作者：
Augur, Isabel F.;Wyckoff, Andrew R.;Peters, Jamie
通讯作者：
Peters, Jamie
影响因子：
5.3
作者：
Gutman, Andrea L.;Nett, Kelle E.;LaLumiere, Ryan T.
通讯作者：
LaLumiere, Ryan T.
影响因子：
3.4
作者：
Gutman AL;Ewald VA;Cosme CV;Worth WR;LaLumiere RT
通讯作者：
LaLumiere RT
DOI：
10.1073/pnas.0913016107
发表时间：
2010-04-06
影响因子：
11.1
作者：
Popa, Daniela;Duvarci, Sevil;Pare, Denis
通讯作者：
Pare, Denis