Use of a Multicomponent Reaction for Chemoselective Derivatization of Multiple Classes of Metabolites
Use of a Multicomponent Reaction for Chemoselective Derivatization of Multiple Classes of Metabolites
复制标题
使用多组分反应对多类代谢物进行化学选择性衍生化
作者：
Kyle A Totaro;Babajide O. Okandeji;Jason K. Sello
我们证明了UGI反应能够使生物胺、羧酸、醛或酮在一组反应条件下与生色团进行化学选择性衍生化，即使在水存在的情况下也是如此。神经递质、激素、疾病生物标志物和其他代谢物的衍生化是系统生物学和诊断医学的好兆头。
We demonstrate that the Ugi reaction enables chemoselective derivatization of biological amines, carboxylic acids, aldehydes, or ketones with a chromophore under one set of reaction conditions, even in the presence of water. Derivatization of neurotransmitters, hormones, disease biomarkers and other metabolites bodes well for systems biology and diagnostic medicine.
DOI：
10.1016/j.jchromb.2008.04.031
发表时间：
2008-08-15
影响因子：
3
作者：
Lu, Wenyun;Bennett, Bryson D.;Rabinowitz, Joshua D.
通讯作者：
Rabinowitz, Joshua D.
影响因子：
15
作者：
Pirrung, MC;Das Sarma, K
通讯作者：
Das Sarma, K