Developmental regulation of mossy fiber afferent interactions with target granule cells.
Developmental regulation of mossy fiber afferent interactions with target granule cells.
复制标题
苔藓纤维传入与目标颗粒细胞相互作用的发育调节。
DOI：
10.1006/dbio.1997.8837
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Mason,CA
中科院分区：
文献类型：
--
作者：
Zhang,Q;Mason,CA
在基于纯化的靶小脑颗粒神经元和传入纤维外植体的体外模型系统中，当它们遇到颗粒神经元时，桥脑苔藓纤维传入纤维通过接触介导的机制停止生长。本文在两种培养系统中研究了颗粒细胞发出的停止信号的发育调节和苔藓纤维对停止信号的反应。颗粒神经元切片或作为解离细胞出生后（P）4和P7小脑更有效的逮捕P0脑桥神经突起比年轻（P0-P2）或老年人（P14）颗粒神经元。相反，脑桥神经突在胚胎（E）18天，在他们的正常增长期间向小脑，广泛增长的所有年龄的小脑切片从P0到P10和分离的P4颗粒神经元。当E18外植体在接种前在新生小脑细胞条件培养基中维持2天时，E18脑桥外植体对来自P4颗粒细胞的停止信号的反应更灵敏。这些结果表明，停止信号和传入神经对它的反应是发育调节的。此外，目标区域内的因素可能会引发这些相互作用。
In anin vitromodel system based on purified target cerebellar granule neurons and explants of afferents, pontine mossy fiber afferents stop growing through contact-mediated mechanisms when they encounter granule neurons. Here we studied the developmental regulation of the stop signal posed by granule cells and the response of mossy fibers to the stop signal in two culture systems. Granule neurons presented in slices or as dissociated cells from postnatal day (P) 4 and P7 cerebellum were more potent in the arrest of P0 pontine neurites than younger (P0-P2) or older (up to P14) granule neurons. In contrast, pontine neurites at embryonic day (E) 18, during their period of normal growth toward the cerebellum, grew extensively on both cerebellar slices of all ages from P0 to P10 and dissociated P4 granule neurons. When E18 explants were maintained for 2 days before plating in medium conditioned by neonatal cerebellar cells, E18 pontine explants were rendered more responsive to the stop signal from P4 granule cells. These results indicate that the stop signal, and the response of afferents to it, are developmentally regulated. Moreover, factors within the target region may initiate these interactions.
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影响因子：
2.5
作者：
ALTMAN, J
通讯作者：
ALTMAN, J
影响因子：
2.7
作者：
L. Stevens;S. Landis;S. Landis
通讯作者：
L. Stevens;S. Landis;S. Landis
小白蛋白免疫组织化学证明了大脑中初级前庭纤维显示的轴突生长的两个不同阶段和机制
影响因子：
3.3
作者：
Roger J. Morris;J. Beech;Claus W. Heizmann
通讯作者：
Claus W. Heizmann
DOI：
10.1002/neu.480210803
发表时间：
1990-12-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
GAMBARANA, C;PITTMAN, R;SIEGEL, RE
通讯作者：
SIEGEL, RE
靶细胞衍生的传入轴突生长停止信号的特异性。
DOI：
10.1002/neu.480230511
发表时间：
1992
期刊：
Journal of neurobiology
影响因子：
--
作者：
Baird,DH;Baptista,CA;Wang,LC;Mason,CA
通讯作者：
Mason,CA