Neural representations of airflow in Drosophila mushroom body.
Neural representations of airflow in Drosophila mushroom body.
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DOI：
10.1371/journal.pone.0004063
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发表时间：
2008
期刊：
影响因子：
3.7
通讯作者：
Zhong Y
中科院分区：
文献类型：
--
作者：
Mamiya A;Beshel J;Xu C;Zhong Y
果蝇蘑菇体（MB）是一个高级嗅觉中心，嗅觉和其他感觉信息被认为是相关的。然而，果蝇的MB神经元如何对气味以外的感觉刺激作出反应尚不清楚。在这里，我们的特点是MB神经元的反应，在气流的变化，刺激与气味感知。MB神经元的体内钙成像显示出令人惊讶的强大和动态的反应，气流刺激。这种反应依赖于第三触角节的运动，表明约翰斯顿的器官可能是检测气流。然而，在MB的输出叶中，不同类型的MB神经元对气流开和关的反应模式不同。此外，对反应的详细空间分析表明，即使在由单一类型的MB神经元组成的叶内，也存在对气流开和关的不同反应的细分。这些在一个单一的叶内的亚类在果蝇中以刻板的方式组织起来。这是第一次，我们表明，气流的变化影响MB神经元显着，这些影响在空间上组织成比以前定义的MB神经元类型更小的部门。
The Drosophila mushroom body (MB) is a higher olfactory center where olfactory and other sensory information are thought to be associated. However, how MB neurons of Drosophila respond to sensory stimuli other than odor is not known. Here, we characterized the responses of MB neurons to a change in airflow, a stimulus associated with odor perception. In vivo calcium imaging from MB neurons revealed surprisingly strong and dynamic responses to an airflow stimulus. This response was dependent on the movement of the 3rd antennal segment, suggesting that Johnston's organ may be detecting the airflow. The calyx, the input region of the MB, responded homogeneously to airflow on. However, in the output lobes of the MB, different types of MB neurons responded with different patterns of activity to airflow on and off. Furthermore, detailed spatial analysis of the responses revealed that even within a lobe that is composed of a single type of MB neuron, there are subdivisions that respond differently to airflow on and off. These subdivisions within a single lobe were organized in a stereotypic manner across flies. For the first time, we show that changes in airflow affect MB neurons significantly and these effects are spatially organized into divisions smaller than previously defined MB neuron types.
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