Afferent spontaneous electrical activity promotes the survival of target cells in the developing retinotectal system of the rat
Afferent spontaneous electrical activity promotes the survival of target cells in the developing retinotectal system of the rat
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传入自发电活动促进大鼠视网膜顶盖系统发育中靶细胞的存活
DOI：
--
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发表时间：
1993
影响因子：
5.3
通讯作者：
Bruna Margheritti
中科院分区：
文献类型：
--
作者：
Lucia Galli;Monica Ensini;Eleonora Fusco;Angela Gravina;Bruna Margheritti
This study was undertaken to investigate the role of afferent spontaneous electrical activity in regulating death of target cells in the developing mammalian visual system. We show here that naturally occurring cell death in the rat superior colliculus is greatly augmented when the spontaneous firing of retinal ganglion cells is transiently blocked with TTX. An increased number of dying cells is already observed after 1 hr of afferent blockade. A 50% increase of cell death is reached after 3 hr of blockade, an effect that closely parallels increased cell death caused by eye enucleation after similar intervals of time. These results suggest that, during development, input cells exert a trophic action on target cells, which is prevented by silencing input electrical activity. A likely explanation of this effect is that the spontaneous firing of input cells causes the release by afferent fibers of a trophic agent promoting the survival of target cells.
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生长中的胚胎神经元诱发乙酰胆碱的释放。
DOI：
10.1073/pnas.84.8.2540
发表时间：
1987
影响因子：
11.1
作者：
Sun,YA;Poo,MM
通讯作者：
Poo,MM
DOI：
10.1002/neu.480210112
发表时间：
1990
期刊：
Journal of neurobiology
影响因子：
--
作者：
E. Rubel;R. L. Hyson;D. Durham
通讯作者：
E. Rubel;R. L. Hyson;D. Durham
新型神经营养因子、受体和癌基因。
影响因子：
13.9
作者：
Walicke,PA
通讯作者：
Walicke,PA
眼内河豚毒素对大鼠出生后视神经轴突数量减少的影响。
影响因子：
2.9
作者：
O'Leary,DD;Crespo,D;Fawcett,JW;Cowan,WM
通讯作者：
Cowan,WM
影响因子：
56.9
作者：
MEISTER, M;WONG, ROL;SHATZ, CJ
通讯作者：
SHATZ, CJ