Does vitamin D status track through adolescence?1
Does vitamin D status track through adolescence?1
复制标题
维生素 D 状态会贯穿整个青春期吗？1
DOI：
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发表时间：
2015
影响因子：
7.1
通讯作者：
J. Pettifor
中科院分区：
文献类型：
--
作者：
M. Poopedi;S. Norris;L. Micklesfield;J. Pettifor
背景：据我们所知，目前还没有关于青少年维生素D水平长期变化的研究报告。目的：为了确定健康青少年是否会追踪维生素D状态，我们对生活在南非约翰内斯堡（纬度26°S）的青少年进行了纵向队列研究，在10年的时间里，每2年评估25-羟基维生素D [25(OH)D]的变异性。设计：11岁至20岁之间有≥3次可获得血液样本的健康青少年纳入研究。在504名儿童中，有99名符合标准。测定各时间点的平均25(OH)D浓度，并以11年的个体25(OH)D z评分为参考。所有受试者的25(OH)D浓度均在一次测定中测定。结果：青少年早期和后期25(OH)D之间没有发现显著相关性，尽管11年级和13年级之间存在显著相关性（r = 0.71, P < 0.0001）， 15、17和20年级之间存在显著相关性（r≥0.65,P < 0.0001）。计算了所有年龄组中25(OH)D浓度从11年级起变化>20 nmol/L的青少年的百分比：12%的队列在13岁时变化>20 nmol/L，而在20岁时为46%。超过一半（53%）的研究对象在11岁到20岁之间改变了他们的维生素D水平，三分之一的青少年在同一时期从维生素D摄入充足变为维生素D摄入不足。结论：数据表明，在单个时间点测量25(OH)D并不能反映青少年的长期维生素D状况。这些发现可能会让人怀疑那些表明维生素D水平与各种疾病状态之间存在关联的研究的准确性，而这些疾病状态中维生素D水平仅被测量一次。
Background: To our knowledge, no studies have reported on the long-term variability of vitamin D status in adolescents. Objective: To determine whether tracking of vitamin D status occurs in healthy adolescents, we assessed the variability of 25-hydroxyvitamin D [25(OH)D] every 2 y over a 10-y period in a longitudinal cohort of adolescents living in Johannesburg, South Africa (latitude 26°S). Design: Healthy adolescents who had blood samples available on ≥3 occasions between 11 and 20 y of age were included in the study. Of the cohort of 504 children, 99 met the criteria. The mean 25(OH)D concentration at each time point was measured, and the individual 25(OH)D z scores based on year 11 values were used as the reference. All 25(OH)D concentrations for a subject were measured in a single assay. Results: No significant correlation was found between 25(OH)D in the earlier and later years of adolescence, although significant correlations were found between year 11 and year 13 (r = 0.71, P < 0.0001) and between years 15, 17, and 20 (r ≥ 0.65, P < 0.0001). The percentage of adolescents whose 25(OH)D concentration changed by >20 nmol/L from year 11 was calculated for all age groups: 12% of the cohort had a change of >20 nmol/L at 13 y of age compared with 46% at 20 y of age. Just more than one-half (53%) of the cohort changed their category of vitamin D status between the ages of 11 and 20 y, and one-third of adolescents changed from being replete to insufficient over the same period. Conclusions: The data suggest that the measurement of 25(OH)D at a single time point does not reflect the long-term vitamin D status of an adolescent. These findings may cast doubt on the veracity of those studies that suggest an association of vitamin D status with various disease states in which vitamin D status was measured only once.
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影响因子：
158.5
作者：
Kimm, SYS;Glynn, NW;Liu, K
通讯作者：
Liu, K
影响因子：
6.1
作者：
Holick, Michael F.
通讯作者：
Holick, Michael F.
影响因子：
5.8
作者：
Arunabh, S;Pollack, S;Aloia, JF
通讯作者：
Aloia, JF
影响因子：
7.1
作者：
Holick, MF
通讯作者：
Holick, MF
影响因子：
7.1
作者：
Wortsman, J;Matsuoka, LY;Holick, MF
通讯作者：
Holick, MF