Greater bone formation induction occurred in aged than young cancellous bone sites.
Greater bone formation induction occurred in aged than young cancellous bone sites.
复制标题
老年松质骨部位比年轻松质骨部位发生更大的骨形成诱导。
作者：
Ke,HZ;Jee,WS;Ito,H;Setterberg,RB;Li,M;Lin,BY;Liang,XG;Ma,YF
我们已经确定了前列腺素E2(PGE2)持续治疗对7月龄SD大鼠的老年(非生长)和年轻(生长)松质骨部位的影响的差异。受累部位包括陈旧性的胫骨远端干骺端(DTM)和年轻的胫骨近端干骺端(PTM)，前者有闭合的骨痂，后者生长缓慢，骨痂开放。这项研究包括给予大鼠0、1、3或6 mg PGE2/kg/d治疗60、120和180天。测定DTM和PTM的骨小梁面积百分比的静态和动态组织形态计量学，以及组织参照骨形成率(BFR/TV)。在预处理对照组中，两个干骺端的次级松质骨含量相同(DTM为11%，PTM为13%)，但DTM的骨形成明显减少(DTM为0.6%/年，PTM为41.5%/年)。治疗60d后，DTM和PTM的%Tb.Ar分别增加607%和199%，BFR/TV分别增加近14倍和5倍。这些结果表明，对PGE2处理，DTM的老年干骺端对PGE2的反应要比年轻的PTM干骺端高得多。两个部位120天和180天的治疗结果与60天的治疗结果无显著差异，表明连续每日治疗PGE2的效果在60天后达到平衡。我们得出的结论是，老年干骺端对PGE2治疗的反应比年轻的生长干骺端更敏感。
We have determined the differences in the effects of continual prostaglandin E2(PGE2) treatment in aged (non-growing) and young (growing) cancellous bone sites in 7-month-old Sprague-Dawley rats. The sites involved are the aged distal tibial metaphysis (DTM) with a closed epiphysis and the young proximal tibial metaphysis (PTM) with a slow growing, open epiphysis. The study involved rats treated with 0, 1, 3 or 6 mg PGE2/kg/d for 60, 120 and 180 days. Static and dynamic histomorphometry of percent trabecular area, and tissue-referent bone formation rate (BFR/TV) were determined in both DTM and PTM. In pretreatment controls, the secondary spongiosa of the two metaphyses contain the same amount of cancellous bone (11% in DTM vs. 13% in PTM), but markedly less bone formation in DTM (0.6%/y in DTM vs. 41.5%/y in PTM). After 60 days of 6 mg PGE2/kg/d treatment, % Tb.Ar was increased 607% in DTM and 199% in PTM, BFR/TV was increased to nearly 14 fold in DTM and only 5 fold in PTM. These results indicated the aged metaphysis of the DTM was much more responsive to PGE2treatment than young, growing metaphysis of the PTM. The results of 120 and 180 days treatment did not significantly differ from 60 days treatment in both sites, indicating that the effect of continuous daily PGE2treatment were in equilibrium after 60 days. We concluded that aged metaphysis was much more responsive to PGE2treatment than young growing metaphysis.
DOI：
10.1016/0169-6009(92)90809-r
发表时间：
1992-09-01
期刊：
BONE AND MINERAL
影响因子：
--
作者：
FROST, HM;JEE, WSS
通讯作者：
JEE, WSS
DOI：
10.1016/0169-6009(91)90109-d
发表时间：
1991-10-01
期刊：
BONE AND MINERAL
影响因子：
--
作者：
JEE, WSS;KE, HZ;LI, XJ
通讯作者：
LI, XJ
局部刮除小鼠骨髓中集落形成单位的起源和恢复。
影响因子：
20.3
作者：
W. Knospe;W. Knospe;W. Knospe;Stephanie Ann Gregory;Stephanie Ann Gregory;Stephanie Ann Gregory;Salah G. Husseini;Salah G. Husseini;W. Fried;F. Trobaugh;F. Trobaugh
通讯作者：
F. Trobaugh