Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.
Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.
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DOI：
10.1001/archgenpsychiatry.2012.124
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发表时间：
2012-08
影响因子：
--
通讯作者：
Bierut, Laura J.
中科院分区：
文献类型：
--
作者：
Hartz, Sarah M.;Short, Susan E.;Saccone, Nancy L.;Culverhouse, Robert;Chen, LiShiun;Schwantes-An, Tae-Hwi;Coon, Hilary;Han, Younghun;Stephens, Sarah H.;Sun, Juzhong;Chen, Xiangning;Ducci, Francesca;Dueker, Nicole;Franceschini, Nora;Frank, Josef;Geller, Frank;Guobjartsson, Daniel;Hansel, Nadia N.;Jiang, Chenhui;Keskitalo-Vuokko, Kaisu;Liu, Zhen;Lyytikainen, Leo-Pekka;Michel, Martha;Rawal, Rajesh;Hum, Sc;Rosenberger, Albert;Scheet, Paul;Shaffer, John R.;Teumer, Alexander;Thompson, John R.;Vink, Jacqueline M.;Vogelzangs, Nicole;Wenzlaff, Angela S.;Wheeler, William;Xiao, Xiangjun;Yang, Bao-Zhu;Aggen, Steven H.;Balmforth, Anthony J.;Baumeister, Sebastian E.;Beaty, Terri;Bennett, Siiri;Bergen, Andrew W.;Boyd, Heather A.;Broms, Ulla;Campbell, Harry;Chatterjee, Nilanjan;Chen, Jingchun;Cheng, Yu-Ching;Cichon, Sven;Couper, David;Cucca, Francesco;Dick, Danielle M.;Foroud, Tatiana;Furberg, Helena;Giegling, Ina;Gu, Fangyi;Hall, Alistair S.;Hallfors, Jenni;Han, Shizhong;Hartmann, Annette M.;Hayward, Caroline;Heikkila, Kauko;Hewitt, John K.;Hottenga, Jouke Jan;Jensen, Majken K.;Jousilahti, Pekka;Kaakinen, Marika;Kittner, Steven J.;Konte, Bettina;Korhonen, Tellervo;Landi, Maria-Teresa;Laatikainen, Tiina;Leppert, Mark;Levy, Steven M.;Mathias, Rasika A.;McNeil, Daniel W.;Medland, Sarah E.;Montgomery, Grant W.;Muley, Thomas;Murray, Tanda;Nauck, Matthias;North, Kari;Pergadia, Michele;Polasek, Ozren;Ramos, Erin M.;Ripatti, Samuli;Risch, Angela;Ruczinski, Ingo;Rudan, Igor;Salomaa, Veikko;Schlessinger, David;Styrkarsdottir, Unnur;Terracciano, Antonio;Uda, Manuela;Willemsen, Gonneke;Wu, Xifeng;Abecasis, Goncalo;Barnes, Kathleen;Bickeboeller, Heike;Boerwinkle, Eric;Boomsma, Dorret I.;Caporaso, Neil;Duan, Jubao;Edenberg, Howard J.;Francks, Clyde;Gejman, Pablo V.;Gelernter, Joel;Grabe, Hans Joergen;Hops, Hyman;Jarvelin, Marjo-Riitta;Viikari, Jorma;Kahonen, Mika;Kendler, Kenneth S.;Lehtimaki, Terho;Levinson, Douglas F.;Marazita, Mary L.;Marchini, Jonathan;Melbye, Mads;Mitchell, Braxton D.;Murray, Jeffrey C.;Nothen, Markus M.;Penninx, Brenda W.;Raitakari, Olli;Rietschel, Marcella;Rujescu, Dan;Samani, Nilesh J.;Sanders, Alan R.;Schwartz, Ann G.;Shete, Sanjay;Shi, Jianxin;Spitz, Margaret;Stefansson, Kari;Swan, Gary E.;Thorgeirsson, Thorgeir;Volzke, Henry;Wei, Qingyi;Wichmann, H. -Erich;Amos, Christopher I.;Breslau, Naomi;Cannon, Dale S.;Ehringer, Marissa;Grucza, Richard;Hatsukami, Dorothy;Heath, Andrew;Johnson, Eric O.;Kaprio, Jaakko;Madden, Pamela;Martin, Nicholas G.;Stevens, Victoria L.;Stitzel, Jerry A.;Weiss, Robert B.;Kraft, Peter;Bierut, Laura J.
最近的研究表明，每日吸烟量（CPD）与CHRNA 5，rs 16969968的非同义单核苷酸多态性之间存在关联。确定rs 16969968与吸烟之间的关联是否因开始定期吸烟时的年龄而改变。主数据.可用的遗传研究包含CPD的措施和rs 16969968或其代理的基因型。统一的统计分析脚本在本地运行。从43项研究中的94 050名曾经吸烟者开始，我们提取了具有发病年龄信息的重度吸烟者（CPD >20）和轻度吸烟者（CPD ≤10），将样本量减少到33 348。每项研究均分为早发性吸烟者（发病年龄≤16岁）和晚发性吸烟者（发病年龄>16岁），并对每一层的rs 16969968基因型进行重度吸烟与轻度吸烟的logistic回归分析。在每个发病年龄分层内进行荟萃分析。在rs 16969968上有1个危险等位基因的早发性吸烟者在成年后成为重度吸烟者的可能性显著增加（比值比[OR]=1.45; 95%CI，1.36-1.55; n=13 843）（OR = 1.27; 95%CI，1.21-1.33，n = 19 505）（P = .01）。这些结果强调了早发性吸烟者对吸烟的遗传易感性增加。
Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968. To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking. Primary data. Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy. Uniform statistical analysis scripts were run locally. Starting with 94 050 ever-smokers from 43 studies, we extracted the heavy smokers (CPD >20) and light smokers (CPD ≤10) with age-at-onset information, reducing the sample size to 33 348. Each study was stratified into early-onset smokers (age at onset ≤16 years) and late-onset smokers (age at onset >16 years), and a logistic regression of heavy vs light smoking with the rs16969968 genotype was computed for each stratum. Meta-analysis was performed within each age-at-onset stratum. Individuals with 1 risk allele at rs16969968 who were early-onset smokers were significantly more likely to be heavy smokers in adulthood (odds ratio [OR]=1.45; 95% CI, 1.36–1.55; n=13 843) than were carriers of the risk allele who were late-onset smokers (OR = 1.27; 95% CI, 1.21–1.33, n = 19 505) (P = .01). These results highlight an increased genetic vulnerability to smoking in early-onset smokers.
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影响因子：
5.8
作者：
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通讯作者：
de Bakker, Paul I. W.
影响因子：
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作者：
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158.5
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作者：
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通讯作者：
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5.1
作者：
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通讯作者：
Hennrikus, DJ