Neural systems supporting the control of affective and cognitive conflicts.
Neural systems supporting the control of affective and cognitive conflicts.
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DOI：
10.1162/jocn.2009.21129
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发表时间：
2009-09
影响因子：
3.2
通讯作者：
Gabrieli JD
中科院分区：
文献类型：
--
作者：
Ochsner KN;Hughes B;Robertson ER;Cooper JC;Gabrieli JD
尽管许多研究已经研究了控制认知反应的神经基础，但控制相互竞争的情感反应之间冲突的神经系统仍然不清楚。为了解决情感冲突的神经相关性及其与认知冲突的关系，本研究收集了两个版本的埃里克森侧翼任务期间的全脑fMRI数据。在这些任务中，参与者指出了中心目标词的价位(情感任务)或语义类别(认知任务)，而忽略了侧翼词映射到与目标词相同(一致)或不同(不一致)反应的词。总体而言，不一致试验的对比表明，在两种冲突中，双侧后内侧额叶皮质和背外侧PFC都是激活的，而在情感或认知冲突中，吻侧内侧PFC和左腹外侧PFC分别不同地激活。个体差异分析显示，扣带回/腹内侧PFC和左腹外侧PFC的分离区域与反应时干扰的大小呈正相关。综上所述，控制情感和认知冲突依赖于共同的和不同的系统这一发现对于理解控制系统的总体组织及其在临床疾病中的潜在功能障碍具有重要的意义。
Although many studies have examined the neural bases of controlling cognitive responses, the neural systems for controlling conflicts between competing affective responses remain unclear. To address the neural correlates of affective conflict and their relationship to cognitive conflict, the present study collected whole-brain fMRI data during two versions of the Eriksen flanker task. For these tasks, participants indicated either the valence (affective task) or the semantic category (cognitive task) of a central target word while ignoring flanking words that mapped onto either the same (congruent) or a different (incongruent) response as the target. Overall, contrasts of incongruent > congruent trials showed that bilateral dorsal ACC, posterior medial frontal cortex, and dorsolateral pFC were active during both kinds of conflict, whereas rostral medial pFC and left ventrolateral pFC were differentially active during affective or cognitive conflict, respectively. Individual difference analyses showed that separate regions of rostral cingulate/ventromedial pFC and left ventrolateral pFC were positively correlated with the magnitude of response time interference. Taken together, the findings that controlling affective and cognitive conflicts depends upon both common and distinct systems have important implications for understanding the organization of control systems in general and their potential dysfunction in clinical disorders.
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