FMRI and intra-cranial electrocorticography recordings in the same human subjects reveals negative BOLD signal coupled with silenced neuronal activity.
FMRI and intra-cranial electrocorticography recordings in the same human subjects reveals negative BOLD signal coupled with silenced neuronal activity.
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DOI：
10.1007/s00429-021-02342-4
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发表时间：
2022-05
影响因子：
3.1
通讯作者：
Petridou, Natalia
中科院分区：
文献类型：
--
作者：
Fracasso, Alessio;Gaglianese, Anna;Vansteensel, Mariska J.;Aarnoutse, Erik J.;Ramsey, Nick F.;Dumoulin, Serge O.;Petridou, Natalia
通过功能性磁共振成像（fMRI）测量的正血氧水平依赖性（BOLD）反应（PBR）是最常用的非侵入性脑活动测量方法。最近的研究一致表明，BOLD的反应并不完全是积极的。负BOLD反应（NBR）已被报道在响应特定的感官刺激和任务。然而，NBR与潜在的代谢和神经元需求之间的确切关系仍在争论中。在这项研究中，我们调查了负BOLD的神经生理学基础，使用功能磁共振成像和颅内电生理（皮层电图，ECoG）测量从相同的人类参与者。我们表明，对于那些电极，响应视觉刺激，PBR与高频带（HFB）的反应。至关重要的是，NBR与HFB功率响应的缺失和α功率响应的意外降低相关。
Positive blood oxygenation level-dependent (BOLD) responses (PBR), as measured by functional Magnetic Resonance Imaging (fMRI), are the most utilized measurements to non-invasively map activity in the brain. Recent studies have consistently shown that BOLD responses are not exclusively positive. Negative BOLD responses (NBR) have been reported in response to specific sensory stimulations and tasks. However, the exact relationship between NBR and the underlying metabolic and neuronal demand is still under debate. In this study, we investigated the neurophysiological basis of negative BOLD using fMRI and intra-cranial electrophysiology (electrocorticography, ECoG) measurements from the same human participants. We show that, for those electrodes that responded to visual stimulation, PBR are correlated with high-frequency band (HFB) responses. Crucially, NBR were associated with an absence of HFB power responses and an unpredicted decrease in the alpha power responses.
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影响因子：
16.2
作者：
Goense J;Merkle H;Logothetis NK
通讯作者：
Logothetis NK
影响因子：
3.2
作者：
Goense J;Bohraus Y;Logothetis NK
通讯作者：
Logothetis NK
影响因子：
2.5
作者：
Feige, B;Scheffler, K;Seifritz, E
通讯作者：
Seifritz, E
影响因子：
4.8
作者：
Gaglianese A;Harvey BM;Vansteensel MJ;Dumoulin SO;Ramsey NF;Petridou N
通讯作者：
Petridou N
DOI：
10.1097/00004647-200208000-00002
发表时间：
2002-08-01
影响因子：
6.3
作者：
Harel, N;Lee, SP;Kim, SG
通讯作者：
Kim, SG