Natural Killer Cells in Liver Disease and Hepatocellular Carcinoma and the NK Cell-Based Immunotherapy.
Natural Killer Cells in Liver Disease and Hepatocellular Carcinoma and the NK Cell-Based Immunotherapy.
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DOI：
10.1155/2018/1206737
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发表时间：
2018
影响因子：
4.1
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Liu P;Chen L;Zhang H
自然杀伤细胞（NK）在宿主对病毒感染和肿瘤的先天和适应性免疫防御中起着关键作用。NK细胞富含肝脏造血细胞，具有独特的NK储备和功能，保护肝细胞免受肝炎病毒感染或恶性转化。然而，越来越多的证据发现，NK细胞受包括肝细胞癌在内的肝脏疾病和肝癌的调节，其功能受损，不能激活病毒感染细胞或肿瘤细胞的清除，并进一步参与肝损伤和炎症的发病机制。肝脏疾病和肝癌中循环和肝内NK细胞表型和功能的全面表征不仅为疾病发病机制提供了新的见解，而且为开发新的NK细胞治疗策略发现了新的靶点。本文将讨论和总结NK细胞在肝脏疾病和HCC中的表型和功能变化，并对NK细胞免疫治疗包括HCC在内的癌症的方法和进展进行综述。
Nature killer (NK) cells play a critical role in host innate and adaptive immune defense against viral infections and tumors. NK cells are enriched in liver hematopoietic cells with unique NK repertories and functions to safeguard liver cells against hepatitis virus infection or malignancy transformation. However, accumulating evidences were found that the NK cells were modulated by liver diseases and liver cancers including hepatocellular carcinoma (HCC) and showed impaired functions failing to activate the elimination of the viral-infected cells or tumor cells and were further involved in the pathogenesis of liver injury and inflammation. The full characterization of circulation and intrahepatic NK cell phenotype and function in liver disease and liver cancer has not only provided new insight into the disease pathogenesis but has also discovered new targets for developing new NK cell-based therapeutic strategies. This review will discuss and summarize the NK cell phenotypic and functional changes in liver disease and HCC, and the NK cell-based immunotherapy approaches and progresses for cancers including HCC will also be reviewed.
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