In vivo, transcutaneous glucose sensing using surface-enhanced spatially offset Raman spectroscopy: multiple rats, improved hypoglycemic accuracy, low incident power, and continuous monitoring for greater than 17 days.
In vivo, transcutaneous glucose sensing using surface-enhanced spatially offset Raman spectroscopy: multiple rats, improved hypoglycemic accuracy, low incident power, and continuous monitoring for greater than 17 days.
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DOI：
10.1021/ac202343e
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发表时间：
2011-12-01
影响因子：
7.4
通讯作者：
Van Duyne, Richard P.
中科院分区：
文献类型：
--
作者：
Ma, Ke;Yuen, Jonathan M.;Shah, Nilam C.;Walsh, Joseph T., Jr.;Glucksberg, Matthew R.;Van Duyne, Richard P.
本文介绍了使用表面增强空间偏移拉曼光谱 (SESORS) 定量体内经皮葡萄糖传感的最新进展。纳米球上的银膜 (AgFON) 表面用混合自组装单层 (SAM) 进行功能化，并植入 Sprague-Dawley 大鼠皮下。监测六只大鼠间质液中的葡萄糖浓度。结果显示出出色的准确性和一致性。值得注意的是，低葡萄糖浓度 (< 80 mg/dL) 的校准均方根误差 (RMSEC) (3.6 mg/dL) 和预测均方根误差 (RMSEP) (13.7 mg/dL) 低于当前国际组织标准 (ISO/DIS 15197) 的要求。商业上可用的葡萄糖传感技术都无法在低血糖发作期间达到足够的准确性。此外，我们的传感器在植入后 17 天即可展示其功能，其中包括在人体皮肤暴露激光安全水平下仅进行一次校准的 12 天。因此，我们基于 SERS 的传感器有望应对可靠的连续葡萄糖传感系统的挑战，实现最佳血糖控制。
This paper presents the latest progress on quantitative, in vivo, transcutaneous glucose sensing using surface enhanced spatially offset Raman spectroscopy (SESORS). Silver film over nanosphere (AgFON) surfaces were functionalized with a mixed self-assembled monolayer (SAM) and implanted subcutaneously in Sprague-Dawley rats. The glucose concentration was monitored in the interstitial fluid of six separate rats. The results demonstrated excellent accuracy and consistency. Remarkably, the root mean square error of calibration (RMSEC) (3.6 mg/dL) and the root mean square error of prediction (RMSEP) (13.7 mg/dL) for low glucose concentration (< 80 mg/dL) is lower than the current International Organization Standard (ISO/DIS 15197) requirements. None of the commercially available glucose sensing techniques can achieve enough accuracy during hypoglycemic episodes. Additionally, our sensor demonstrated functionality up 17 days after implantation, including 12 days under the laser safety level for human skin exposure with only one time calibration. Therefore, our SERS based sensor shows promise for the challenge of reliable continuous glucose sensing systems for optimal glycemic control.
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