S-glutathionylation, friend or foe in cardiovascular health and disease.
S-glutathionylation, friend or foe in cardiovascular health and disease.
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DOI：
10.1016/j.redox.2020.101693
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发表时间：
2020-10
期刊：
影响因子：
11.4
通讯作者：
Pattillo CB
中科院分区：
文献类型：
--
作者：
Rashdan NA;Shrestha B;Pattillo CB
谷氨酸是一种低分子量的硫醇，在细胞中以高水平存在。细胞中高水平的谷胱甘肽使其成为有助于细胞氧化还原稳态的最丰富的抗氧化剂之一。作为一般规则，在整个心血管疾病和进展过程中，存在氧化还原稳态的失衡，其特征在于活性氧物质过量产生和谷胱甘肽产生不足。随着对这些不平衡的研究的继续，越来越多地观察到谷胱甘肽浓度驱动各种生理和病理信号反应。有趣的是，除了直接作为抗氧化剂外，谷胱甘肽还能够通过化学相互作用和酶介导的事件对蛋白质进行翻译后修饰（S-谷胱甘肽化）。本文将讨论化学和酶为基础的S-谷胱甘肽化的蛋白质参与心血管疾病和血管生成。
Glutathione is a low molecular weight thiol that is present at high levels in the cell. The high levels of glutathione in the cell make it one of the most abundant antioxidants contributing to cellular redox homeostasis. As a general rule, throughout cardiovascular disease and progression there is an imbalance in redox homeostasis characterized by reactive oxygen species overproduction and glutathione underproduction. As research into these imbalances continues, glutathione concentrations are increasingly being observed to drive various physiological and pathological signaling responses. Interestingly in addition to acting directly as an antioxidant, glutathione is capable of post translational modifications (S-glutathionylation) of proteins through both chemical interactions and enzyme mediated events. This review will discuss both the chemical and enzyme-based S-glutathionylation of proteins involved in cardiovascular pathologies and angiogenesis.
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影响因子：
64.5
作者：
Alegre-Cebollada J;Kosuri P;Giganti D;Eckels E;Rivas-Pardo JA;Hamdani N;Warren CM;Solaro RJ;Linke WA;Fernández JM
通讯作者：
Fernández JM
影响因子：
4.1
作者：
Abhinand, Chandran S.;Raju, Rajesh;Sudhakaran, Perumana R.
通讯作者：
Sudhakaran, Perumana R.
影响因子：
4.8
作者：
Aracena-Parks, Paula;Goonasekera, Sanjeewa A.;Hamilton, Susan L.
通讯作者：
Hamilton, Susan L.
影响因子：
5.4
作者：
Brundu, Serena;Palma, Linda;Fraternale, Alessandra
通讯作者：
Fraternale, Alessandra
影响因子：
4.8
作者：
Beer, SM;Taylor, ER;Murphy, MP
通讯作者：
Murphy, MP