Novel Concepts for Inducing Final Oocyte Maturation in In Vitro Fertilization Treatment.
Novel Concepts for Inducing Final Oocyte Maturation in In Vitro Fertilization Treatment.
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DOI：
10.1210/er.2017-00236
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发表时间：
2018-10-01
影响因子：
20.3
通讯作者：
Dhillo WS
中科院分区：
文献类型：
--
作者：
Abbara A;Clarke SA;Dhillo WS
不孕症影响到六分之一的人口，越来越多的夫妇需要辅助生殖技术治疗。体外受精(IVF)治疗最常用的是使用外源性FSH诱导卵泡生长和使用人绒毛膜促性腺激素(HCG)诱导最终卵母细胞成熟。然而，hCG可能会导致潜在的威胁生命的医源性并发症-卵巢过度刺激综合征(OHSS)，这可能会在其他健康的女性中导致相当大的发病率，甚至很少，甚至死亡。在过去的二十年中，GnRH激动剂(GnRHas)的使用被率先用于提供一种更安全的选择来诱导最终的卵母细胞成熟。最近，下丘脑GnRH释放的调节剂-神经肽Kispeptin被研究为一种新的卵母细胞成熟诱导剂。用来诱导卵母细胞成熟的激素刺激对体外受精治疗的成功(取卵和植入的机会)和安全性(OHSS的风险)有重要影响。本文就hCG、GnRHa、联合应用GnRHa和hCG、重组人促黄体生成素或Kispeptin等激素途径诱导卵母细胞成熟的实验和临床资料进行综述。我们还检查了最终卵母细胞成熟的诱导剂给药时间与卵泡生长参数和随后的取卵间隔之间的关系的证据。综上所述，我们回顾了在临床实践中用于诱导最终卵母细胞成熟的主要激素方法的有效性和安全性的数据，以及一些可能在未来提供新的替代方法的新方法。
Infertility affects one in six of the population and increasingly couples require treatment with assisted reproductive techniques. In vitro fertilization (IVF) treatment is most commonly conducted using exogenous FSH to induce follicular growth and human chorionic gonadotropin (hCG) to induce final oocyte maturation. However, hCG may cause the potentially life-threatening iatrogenic complication “ovarian hyperstimulation syndrome” (OHSS), which can cause considerable morbidity and, rarely, even mortality in otherwise healthy women. The use of GnRH agonists (GnRHas) has been pioneered during the last two decades to provide a safer option to induce final oocyte maturation. More recently, the neuropeptide kisspeptin, a hypothalamic regulator of GnRH release, has been investigated as a novel inductor of oocyte maturation. The hormonal stimulus used to induce oocyte maturation has a major impact on the success (retrieval of oocytes and chance of implantation) and safety (risk of OHSS) of IVF treatment. This review aims to appraise experimental and clinical data of hormonal approaches used to induce final oocyte maturation by hCG, GnRHa, both GnRHa and hCG administered in combination, recombinant LH, or kisspeptin. We also examine evidence for the timing of administration of the inductor of final oocyte maturation in relationship to parameters of follicular growth and the subsequent interval to oocyte retrieval. In summary, we review data on the efficacy and safety of the major hormonal approaches used to induce final oocyte maturation in clinical practice, as well as some novel approaches that may offer fresh alternatives in future.
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影响因子：
4
作者：
Bosdou, Julia K.;Kolibianakis, Efstratios M.;Tarlatzis, Basil
通讯作者：
Tarlatzis, Basil
影响因子：
5.2
作者：
Benmachiche, Abdelhamid;Benbouhedja, Sebti;Humaidan, Peter
通讯作者：
Humaidan, Peter
影响因子：
3.6
作者：
ADAMS, TE;CUMMING, S;ADAMS, BM
通讯作者：
ADAMS, BM
影响因子：
2
作者：
Baum, M.;Machtinger, R.;Hourvitz, A.
通讯作者：
Hourvitz, A.
DOI：
10.1093/humrep/dex253
发表时间：
2017-09-01
期刊：
Human reproduction (Oxford, England)
影响因子：
--
作者：
Abbara A;Clarke S;Islam R;Prague JK;Comninos AN;Narayanaswamy S;Papadopoulou D;Roberts R;Izzi-Engbeaya C;Ratnasabapathy R;Nesbitt A;Vimalesvaran S;Salim R;Lavery SA;Bloom SR;Huson L;Trew GH;Dhillo WS
通讯作者：
Dhillo WS