Palmitic acid-rich oils with and without interesterification lower postprandial lipemia and increase atherogenic lipoproteins compared with a MUFA-rich oil: A randomized controlled trial.
Palmitic acid-rich oils with and without interesterification lower postprandial lipemia and increase atherogenic lipoproteins compared with a MUFA-rich oil: A randomized controlled trial.
复制标题
与富含MUFA的油相比，有或没有酯交换的富含棕榈酸的油可降低餐后脂血症并增加致动脉粥样硬化的脂蛋白：一项随机对照试验。
DOI：
10.1093/ajcn/nqaa413
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发表时间：
2021-05-08
期刊：
影响因子：
--
通讯作者：
Berry SE
中科院分区：
文献类型：
--
作者：
Mills CE;Harding SV;Bapir M;Mandalari G;Salt LJ;Gray R;Fielding BA;Wilde PJ;Hall WL;Berry SE
酯交换(IE)脂肪被广泛用于替代反式脂肪；然而，人们对其新陈代谢知之甚少。为了测试经常食用的IE与非IE等价物脂肪相比对体内餐后和体外脂肪代谢的影响，并与参照油[菜籽油(RO)]进行比较。对45~75岁的健康成人(n=20)进行了双盲、3期交叉、随机对照试验，评价了餐后血浆三酰甘油和脂蛋白对一顿试验餐(50g脂肪)的反应(包括稳定同位素示踪)，试验脂肪为IE 80：20棕榈油硬脂/棕榈核脂肪、相同的非IE脂肪和RO(对照)。在体外，利用动态胃模型(DGM)探讨了消化机制。非IE组血浆三酰甘油曲线下8h增量面积低于RO组[-1.7mmo1/L⋅h(95%CI：-3.3，-0.0)]，但IE组与RO组、IE组与非IE组比较差异无统计学意义。IE组和非IE组的低密度脂蛋白颗粒小于RO组(P<0.005)。IE组和非IE组的特大号、特大号和大号VLDL颗粒浓度在6-8小时高于RO组(P<0.05)。IE脂肪与非IE脂肪血浆中[13C]棕榈酸的出现无明显差异。DGM显示IE和非IE膳食的相分离和SFA的延迟释放与RO不同。通过稳定同位素和DGM分析，酯交换没有改变脂肪消化、餐后脂血症或脂代谢。尽管富含SFA的脂肪降低了血脂，但相对于RO，富含SFA的脂肪增加了导致动脉粥样硬化的大的三酰甘油残留物和小的低密度脂蛋白颗粒，这为将SFA与心血管疾病风险联系起来的机制证据增加了一个新的餐后维度。
Interesterified (IE) fats are widely used in place of trans fats; however, little is known about their metabolism. To test the impact of a commonly consumed IE compared with a non-IE equivalent fat on in vivo postprandial and in vitro lipid metabolism, compared with a reference oil [rapeseed oil (RO)]. A double-blinded, 3-phase crossover, randomized controlled trial was performed in healthy adults (n = 20) aged 45–75 y. Postprandial plasma triacylglycerol and lipoprotein responses (including stable isotope tracing) to a test meal (50 g fat) were evaluated over 8 h. The test fats were IE 80:20 palm stearin/palm kernel fat, an identical non-IE fat, and RO (control). In vitro, mechanisms of digestion were explored using a dynamic gastric model (DGM). Plasma triacylglycerol 8-h incremental area under the curves were lower following non-IE compared with RO [–1.7 mmol/L⋅h (95% CI: –3.3, –0.0)], but there were no differences between IE and RO or IE and non-IE. LDL particles were smaller following IE and non-IE compared with RO (P = 0.005). Extra extra large, extra large, and large VLDL particle concentrations were higher following IE and non-IE compared with RO at 6–8 h (P < 0.05). No differences in the appearance of [13C]palmitic acid in plasma triacylglycerol were observed between IE and non-IE fats. DGM revealed differences in phase separation of the IE and non-IE meals and delayed release of SFAs compared with RO. Interesterification did not modify fat digestion, postprandial lipemia, or lipid metabolism measured by stable isotope and DGM analysis. Despite the lower lipemia following the SFA-rich fats, increased proatherogenic large triacylglycerol-rich lipoprotein remnant and small LDL particles following the SFA-rich fats relative to RO adds a new postprandial dimension to the mechanistic evidence linking SFAs to cardiovascular disease risk.
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影响因子：
13.6
作者：
Lindman, Anja S.;Veierod, M. B.;Tverdal, A.;Pedersen, J. I.;Selmer, R.
通讯作者：
Selmer, R.
影响因子：
6
作者：
Jackson, KG;Knapper-Francis, JME;Williams, CM
通讯作者：
Williams, CM
影响因子：
4.4
作者：
Marciani, L;Bush, D;Gowland, PA
通讯作者：
Gowland, PA
影响因子：
39.3
作者：
Boren, Jan;Chapman, M. John;Ginsberg, Henry N.
通讯作者：
Ginsberg, Henry N.
影响因子：
37.8
作者：
Pradhan, Aruna D.;Aday, Aaron W.;Ridker, Paul M.
通讯作者：
Ridker, Paul M.