Nonfasting triglycerides and risk of cardiovascular death in men and women from the Norwegian Counties Study.
Nonfasting triglycerides and risk of cardiovascular death in men and women from the Norwegian Counties Study.
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DOI：
10.1007/s10654-010-9501-1
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发表时间：
2010-11
影响因子：
13.6
通讯作者：
Selmer, R.
中科院分区：
文献类型：
--
作者：
Lindman, Anja S.;Veierod, M. B.;Tverdal, A.;Pedersen, J. I.;Selmer, R.
非空腹甘油三酯与心血管疾病 (CVD) 之间的关联最近已得到证实。本研究的目的是调查非空腹甘油三酯作为男性和女性 CVD 死亡率的预测因子。 1974 年至 2007 年挪威县研究共有 86,261 名参与者，最初年龄在 20 岁至 50 岁之间，且没有 CVD。我们根据非空腹甘油三酯水平估算了 CVD、缺血性心脏病 (IHD)、中风和所有原因导致的死亡风险比 (HR)。平均随访时间为 27.0 年。共有 9,528 名男性死亡（3,620 人死于 CVD，2,408 人死于中风，2,408 人死于中风），总共有 5,267 名女性死亡（1,296 人死于 CVD，626 人死于中风，360 人死于中风）。调整 HDL 胆固醇以外的 CVD 危险因素后，非空腹甘油三酯每增加 1 mmol/l，全因死亡率的 HR (95% CI) 分别为 1.16 (1.13–1.20)、1.20 (1.14–1.27)、1.26 (1.19–1.34) 和 1.09 (0.96–1.23)。女性的 CVD、IHD 和中风死亡率。男性的相应数字为 1.03 (1.01–1.04)、1.03 (1.00–1.05)、1.03 (1.00–1.06) 和 0.99 (0.92–1.07)。在测量 HDL 胆固醇的子样本中（n = 40,144），在调整 HDL 胆固醇后，在女性中观察到的 CVD 死亡率和甘油三酯之间的关联消失了。在包括弗雷明汉冠心病风险评分的模型中，甘油三酯的影响在男性和女性中都消失了。总之，非空腹甘油三酯与女性和男性的 CVD 死亡风险增加相关。然而，对主要心血管危险因素的调整减弱了这种影响。除了弗雷明汉冠心病风险评分之外，非空腹甘油三酯没有增加男性和女性心血管疾病死亡率的预测信息。
The association between nonfasting triglycerides and cardiovascular disease (CVD) has recently been actualized. The aim of the present study was to investigate nonfasting triglycerides as a predictor of CVD mortality in men and women. A total of 86,261 participants in the Norwegian Counties Study 1974–2007, initially aged 20–50 years and free of CVD were included. We estimated hazard ratios (HRs) for deaths from CVD, ischemic heart disease (IHD), stroke and all causes by level of nonfasting triglycerides. Mean follow-up was 27.0 years. A total of 9,528 men died (3,620 from CVD, 2,408 IHD, 543 stroke), and totally 5,267 women died (1,296 CVD, 626 IHD, 360 stroke). After adjustment for CVD risk factors other than HDL-cholesterol, the HRs (95% CI) per 1 mmol/l increase in nonfasting triglycerides were 1.16 (1.13–1.20), 1.20 (1.14–1.27), 1.26 (1.19–1.34) and 1.09 (0.96–1.23) for all cause mortality, CVD, IHD, and stroke mortality in women. Corresponding figures in men were 1.03 (1.01–1.04), 1.03 (1.00–1.05), 1.03 (1.00–1.06) and 0.99 (0.92–1.07). In a subsample where HDL-cholesterol was measured (n = 40,144), the association between CVD mortality and triglycerides observed in women disappeared after adjustment for HDL-cholesterol. In a model including the Framingham CHD risk score the effect of triglycerides disappeared in both men and women. In conclusion, nonfasting triglycerides were associated with increased risk of CVD death for both women and men. Adjustment for major cardiovascular risk factors, however, attenuated the effect. Nonfasting triglycerides added no predictive information on CVD mortality beyond the Framingham CHD risk score in men and women.
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影响因子：
168.9
作者：
Sarwar, Nadeem;Sandhu, Manjinder S.;Ricketts, Sally L.;Butterworth, Adam S.;Di Angelantonio, Emanuele;Boelcholdt, S. Matthijs;Ouwehand, Willem;Watkins, Hugh;Samani, Nilesh J.;Saleheen, Danish;Lawlor, Debbie;Reilly, Muredach P.;Hingorani, Aroon D.;Talmud, Philippa J.;Danesh, John;Braund, P. S.;Hall, A. S.;Thompson, J.;Marz, W.;Sivapalaratnam, S.;Soranzo, N.;Trip, M.;Casas, J. P.;Ebrahim, S.;Arsenault, B. J.;Boekholdt, S. M.;Khaw, K. T.;Wareham, N. J.;Grallert, H.;Illig, T.;Humphries, S. E.;Rader, D. J.;He, J.;Clarke, R.;Hamsten, R.;Hopewell, J. C.;Frossard, P.;Deloukas, P.;Ye, S.;Simpson, J. A.;Onat, A.;Komurcu-Bayrak, E.;Martinelli, N.;Olivieri, O.;Girelli, D.;Kivimaki, M.;Kumari, M.;Aouizerat, B. E.;Baum, L.;Campos, H.;Chaaba, R.;Chen, B. S.;Cho, E. Y.;Evans, D.;Hill, J.;Hsu, L. A.;Hubacek, J. A.;Lai, C. Q.;Lee, J. H.;Klos, K.;Liu, H.;Masana, L.;Melegh, B.;Nabika, T.;Ribalta, J.;Ruiz-Narvaez, E.;Thomas, G. N.;Tomlinson, B.;Szalai, C.;Vaverkova, H.;Yamada, Y.;Yang, Y.;Tipping, R. W.;Ford, C. E.;Pressel, S. L.;Ballantyne, C.;Brautbar, A.;Knuiman, M.;Winchup, P. H.;Wannamethee, S. G.;Morris, R. W.;Kiechl, S.;Willeit, J.;Santer, P.;Mayr, A.;Wald, N.;Yarnell, J. W. G.;Gallacher, J.;Casiglia, E.;Tikhonoff, V.;Cushman, M.;Psaty, B. M.;Tracy, R. P.;Tybjaerg-Hansen, A.;Nordestgaard, B. G.;Benn, M.;Frikke-Schmidt, R.;Giampaoli, S.;Palmieri, L.;Panico, S.;Vanuzzo, D.;Pilotto, L.;Gomez de la Camara, A.;Gomez-Gerique, J. A.;Simons, L.;McCallum, J.;Friedlander, Y.;Fowkes, F. G. R.;Lee, A. J.;Taylor, J.;Guralnik, J. M.;Phillips, C. L.;Wallace, W. R.;Blazer, D. G.;Brenner, H.;Raum, E.;Mueller, H.;Rothenbacher, D.;Jansson, J. H.;Wennberg, P.;Nissinen, A.;Donfrancesco, C.;Salomaa, V.;Harald, K.;Pencina, M. J.;Vartiainen, E.;D'Agostino, R. B.;Vasan, R. S.;Bladbjerg, E. M.;Jorgensen, T.;Moller, L.;Jespersen, J.;Dankner, R.;Chetrit, A.;Lubin, F.;Bjoerkelund, C.;Lissner, L.;Bengtsson, C.;Cremer, P.;Nagel, D.;Rodriguez, B.;Dekker, J. M.;Nijpels, G.;Stehouwer, C. D. A.;Sato, S.;Iso, H.;Kitamura, A.;Noda, H.;Salonen, J. T.;Nyssoenen, K.;Tuimainen, T. -P.;Voutilainen, S.;Meade, T. W.;Cooper, J. A.;Kuller, L. H.;Grandits, G.;Gillum, R.;Mussolino, M.;Rimm, E.;Hankinson, S.;Manson, J. A. E.;Pai, J. K.;Bauer, K. A.;Naito, Y.;Amouyel, P.;Arveiler, D.;Evans, A.;Ferrieres, J.;Schulte, H.;Assmann, G.;Packard, C. J.;Sattar, N.;Westendorp, R. G.;Buckley, B. M.;Cantin, B.;Lamarche, B.;Despres, J. -P.;Dagenais, G. R.;Barrett-Connor, E.;Wingard, D. L.;Bettencourt, R.;Gudnason, V.;Aspelund, T.;Sigurdsson, G.;Thorsson, B.;Trevisan, M.;Tunstall-Pedoe, H.;Tavendale, R.;Lowe, G. D. O.;Woodward, M.;Howard, B. V.;Zhang, Y.;Best, L.;Umans, J.;Ben-Shlomo, Y.;Davey-Smith, G.;Njolstad, I.;Mathiesen, E. B.;Lochen, M. L.;Wilsgaard, T.;Ingelsson, E.;Lind, I.;Giedraitis, V.;Michaeelsson, K.;Brunner, E.;Shipley, M.;Ridker, P.;Buring, J.;Shepherd, J.;Cobbe, S. M.;Ford, I.;Robertson, M.;Marin Ibanez, A.;Feskens, E. J. M.;Kromhout, D.;Walker, M.;Watson, S.;Collins, R.;Kaptoge, S.;Perry, P. L.;Sarwar, N.;Thompson, A.;Thompson, S. G.;White, I. R.;Wood, A. M.
通讯作者：
Wood, A. M.
影响因子：
120.7
作者：
Freiberg, Jacob J.;Tybjaerg-Hansen, Anne;Nordestgaard, Borge G.
通讯作者：
Nordestgaard, Borge G.
影响因子：
37.8
作者：
Patel, A;Barzi, F;Woodward, M
通讯作者：
Woodward, M
影响因子：
11.1
作者：
Graff-Iversen, S;Hammar, N;Tonstad, S
通讯作者：
Tonstad, S
影响因子：
3.9
作者：
Bravo, E.;Napolitano, M.
通讯作者：
Napolitano, M.