Cortisol rapidly disrupts prepulse inhibition in healthy men
Cortisol rapidly disrupts prepulse inhibition in healthy men
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皮质醇迅速破坏健康男性的前脉冲抑制
DOI：
10.1016/j.psyneuen.2010.07.002
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发表时间：
2011
影响因子：
3.7
通讯作者：
H. Schächinger
中科院分区：
文献类型：
--
作者：
Steffen Richter;A. Schulz;Carina M. Zech;M. Oitzl;N. Daskalakis;T. Blumenthal;H. Schächinger
众所周知，压力会影响感觉运动门控(用脉冲前惊吓抑制或PPI来测量)，可能会改善对威胁信号的感知，但代价是唤醒状态下的其他输入。应激还会诱导多种自主神经系统和内分泌反应，例如激活下丘脑-垂体-肾上腺轴。后者将导致应激激素皮质醇的释放，众所周知，皮质醇在几个中枢神经系统过程中发挥快速和持续的作用。由于先前的研究没有阐明应激反应成分是否以及哪些应激反应成分可能在感觉运动门控中起中介作用，本研究询问皮质醇和感觉运动门控之间是否存在联系。我们采用单盲和安慰剂对照的受试者内设计，通过评估27名健康男性在无应激、隐蔽的1 mg静脉注射皮质醇之前、期间和之后的PPI来测试皮质醇是否会影响PPI。皮质醇引起PPI迅速下降，给药后20min达最大值，20min后PPI恢复至基础水平。在没有预脉冲的情况下，震级不受影响。静脉注射皮质醇的这种快速效应可能是由非基因组机制介导的。我们认为，应激对感觉运动门控的影响可能是由糖皮质激素介导的。应激激素皮质醇对感觉运动门控的破坏可能有助于强烈和潜在危险的惊吓刺激的处理。
Stress is known to affect sensorimotor gating (measured with prepulse inhibition of startle, or PPI), possibly improving perception of threat signals at the expense of other input during states of arousal. Stress also induces a variety of autonomic nervous system and endocrine responses, such as an activation of the hypothalamic–pituitary–adrenal axis. The latter will result in the release of the stress hormone cortisol which is known to exert rapid and sustained action on several CNS processes. Since previous studies have not clarified whether and which stress response components may mediate effects on sensorimotor gating, this study asked whether a link may exist between cortisol and sensorimotor gating. We tested whether cortisol may affect PPI by assessing PPI before, during, and after non-stressful, covert 1mg IV cortisol infusions in 27 healthy men in a single-blind and placebo-controlled within-subject design. Cortisol induced a rapid reduction of PPI, with its maximum at 20min after administration, and PPI returned to baseline after another 20min. Startle magnitude in the absence of a prepulse was not affected. This rapid effect of the IV cortisol infusions is probably mediated by a non-genomic mechanism. We conclude that stress effects on sensorimotor gating may be mediated by glucocorticoids. The disruption of sensorimotor gating by the stress hormone cortisol may serve the processing of intense and potentially dangerous startling stimuli.
影响因子：
6.6
作者：
Adler, LE;Olincy, A;Freedman, R
通讯作者：
Freedman, R
影响因子：
3.7
作者：
Grillon, C;Davis, M
通讯作者：
Davis, M
患有创伤后应激障碍的儿童的惊吓调节。
DOI：
10.1176/ajp.146.7.866
发表时间：
1989
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Ornitz,EM;Pynoos,RS
通讯作者：
Pynoos,RS