Association of Loneliness and Wisdom With Gut Microbial Diversity and Composition: An Exploratory Study.
Association of Loneliness and Wisdom With Gut Microbial Diversity and Composition: An Exploratory Study.
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DOI：
10.3389/fpsyt.2021.648475
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发表时间：
2021
影响因子：
4.7
通讯作者：
Jeste DV
中科院分区：
文献类型：
--
作者：
Nguyen TT;Zhang X;Wu TC;Liu J;Le C;Tu XM;Knight R;Jeste DV
孤独和智慧对健康和幸福有相反的影响。孤独是一个严重的公共卫生问题，与发病率和死亡率的增加有关。智慧与更好的健康和幸福有关。我们一直发现孤独和智慧之间存在很强的负相关关系。本研究旨在探讨孤独感和智慧与肠道微生物群的关系。184名居住在社区的成年人(28-97岁)完成了有效的基于自我报告的孤独、智慧、同情心、社会支持和社会参与的测量。收集粪便样本，并用16S rRNA测序进行分析。控制了年龄和体重指数的线性回归分析显示，较低的孤独感水平以及较高的智慧、同情心、社会支持和社会参与度与肠道微生物群的系统发育丰富性和多样性有关。偏最小二乘法(偏最小二乘法)分析多元关系提取了两个复合变量。用偏最小二乘法预测α多样性的线性回归模型显示，所有心理社会预测因子的线性组合(包括对孤独感的负负荷和对其他所有变量的正负荷，包括智慧、同情心、社会支持和社会投入)与α多样性显著相关。对于贝塔多样性，同情心和智慧在整个微生物群落组成中占了很大比例的差异。这一发现可能会对减少孤独及其可能与健康相关的不良后果的干预措施产生影响。未来的研究应该探索增加同情心和智慧是否可以改善孤独和整体幸福感以及微生物多样性。
Loneliness and wisdom have opposite effects on health and well-being. Loneliness is a serious public health problem associated with increased morbidity and mortality. Wisdom is associated with better health and well-being. We have consistently found a strong negative correlation between loneliness and wisdom. The present study aimed to investigate the association of loneliness and wisdom with the gut microbiome. One hundred eighty-four community-dwelling adults (28–97 years) completed validated self-report-based measures of loneliness, wisdom, compassion, social support, and social engagement. Fecal samples were collected and profiled using 16S rRNA sequencing. Linear regression analyses, controlling for age and body mass index, revealed that lower levels of loneliness and higher levels of wisdom, compassion, social support, and social engagement were associated with greater phylogenetic richness and diversity of the gut microbiome. Partial least squares (PLS) analysis to investigate multivariate relationships extracted two composite variables. Linear regression model predicting alpha-diversity with PLS components revealed that a linear combination of all psychosocial predictors (with negative loading for loneliness and positive loadings for all others, including wisdom, compassion, social support, and social engagement) was significantly associated with alpha-diversity. For beta-diversity, compassion and wisdom accounted for a significant proportion of variance in overall microbial community composition. Findings may have implications for interventions to reduce loneliness and possibly its health-related adverse consequences. Future research should explore whether increasing compassion and wisdom may improve loneliness and overall well-being as well as microbial diversity.
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影响因子：
16.6
作者：
Day FR;Ong KK;Perry JRB
通讯作者：
Perry JRB
DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.6
作者：
Ardelt, M
通讯作者：
Ardelt, M
影响因子：
5.9
作者：
FAITH, DP
通讯作者：
FAITH, DP
影响因子：
6.4
作者：
Amir A;McDonald D;Navas-Molina JA;Debelius J;Morton JT;Hyde E;Robbins-Pianka A;Knight R
通讯作者：
Knight R