Expression plasticity of Phlebotomus papatasi salivary gland genes in distinct ecotopes through the sand fly season.
Expression plasticity of Phlebotomus papatasi salivary gland genes in distinct ecotopes through the sand fly season.
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DOI：
10.1186/1472-6785-11-24
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发表时间：
2011-10-10
期刊：
影响因子：
--
通讯作者：
McDowell MA
中科院分区：
文献类型：
--
作者：
Coutinho-Abreu IV;Mukbel R;Hanafi HA;Fawaz EY;El-Hossary SS;Wadsworth M;Stayback G;Pitts DA;Abo-Shehada M;Hoel DF;Kamhawi S;Ramalho-Ortigão M;McDowell MA
白蛉唾液可以驱动动物模型中利什曼原虫感染的结果，并且唾液成分被认为是对抗利什曼病的候选疫苗。在白蛉中，天然糖源调节参与膳食消化的蛋白质的活性，并可能影响载体能力。然而，只有少数研究评估了白蛉唾液成分的变异性，重点关注自然栖息地环境因素的影响。为了更好地理解这种相互作用，我们比较了埃及和约旦不同生态栖息地的标本以及每个栖息地整个沙蝇季节的九个 P. papatasi 唾液腺基因的表达谱。大多数被研究的基因在 Swaymeh 的样本中在季节末期上调，此时糖源的可用性由于缺水而减少。另一方面，从阿斯旺采集的样本中这些基因并没有上调，阿斯旺是一个不太容易受到干旱影响的灌溉地区。疾病载体中与载体能力相关的基因的表达可塑性可能在自然栖息地疾病的形成中发挥重要的流行病学作用。
Sand fly saliva can drive the outcome of Leishmania infection in animal models, and salivary components have been postulated as vaccine candidates against leishmaniasis. In the sand fly Phlebotomus papatasi, natural sugar-sources modulate the activity of proteins involved in meal digestion, and possibly influence vectorial capacity. However, only a handful of studies have assessed the variability of salivary components in sand flies, focusing on the effects of environmental factors in natural habitats. In order to better understand such interactions, we compared the expression profiles of nine P. papatasi salivary gland genes of specimens inhabiting different ecological habitats in Egypt and Jordan and throughout the sand fly season in each habitat. The majority of investigated genes were up-regulated in specimens from Swaymeh late in the season, when the availability of sugar sources is reduced due to water deprivation. On the other hand, these genes were not up-regulated in specimens collected from Aswan, an irrigated area less susceptible to drought effects. Expression plasticity of genes involved with vectorial capacity in disease vectors may play an important epidemiological role in the establishment of diseases in natural habitats.
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影响因子：
1.7
作者：
Braks, Marieta A. H.;Carde, Ring T.
通讯作者：
Carde, Ring T.
影响因子：
4.8
作者：
Davidson, Ana D.;Ponce, Eduardo;Ceballos, Gerardo
通讯作者：
Ceballos, Gerardo
影响因子：
2.2
作者：
Drahota, J.;Lipoldova, M.;Rohousova, I.
通讯作者：
Rohousova, I.
DOI：
10.4269/ajtmh.1993.49.598
发表时间：
1993-11-01
影响因子：
3.3
作者：
FRYAUFF, DJ;MODI, GB;YOUSSEF, FG
通讯作者：
YOUSSEF, FG
影响因子：
--
作者：
Hanafi, HA;El Sawaf, BM;Tetreault, GE
通讯作者：
Tetreault, GE