Rapid eye movement sleep deprivation does not affect fear memory reconsolidation in rats
Rapid eye movement sleep deprivation does not affect fear memory reconsolidation in rats
复制标题
快速眼动睡眠剥夺不影响大鼠的恐惧记忆重建
DOI：
10.1016/j.neulet.2009.07.044
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发表时间：
2009-09
影响因子：
2.5
通讯作者：
Peng Li
中科院分区：
文献类型：
--
作者：
Xinping Ouyang;Haifeng Deng;Zhengbang Li;Fulian Huang;Yufeng Yang;Shaowen Tian (田绍文);Peng Li
越来越多的证据表明，睡眠可能与记忆巩固有关。然而，仍然有相对较少的研究探讨了睡眠和记忆再巩固之间的关系。本研究旨在探讨快速眼动睡眠剥夺（RSD）对大鼠线索（实验1）和情境（实验2）恐惧记忆再巩固的影响。行为过程包括四个训练阶段：习惯化、恐惧条件化、再激活和测试。在再激活后立即或6小时后开始对大鼠进行6小时RSD。对照组大鼠在重新激活后立即放回其饲养笼中，不受干扰。与那些推测睡眠在再巩固中的潜在作用的假设相反，我们发现，再激活后RSD无论是从0到6小时还是6到12小时，对线索和背景恐惧记忆的再巩固都没有影响。然而，我们目前的研究结果并没有排除非快速眼动睡眠在恐惧记忆的再巩固或睡眠在其他记忆范式的再巩固中的潜在作用。
There is increasing evidence that sleep may be involved in memory consolidation. However, there remain comparatively few studies that have explored the relationship between sleep and memory reconsolidation. At present study, we tested the effects of rapid eye movement sleep deprivation (RSD) on the reconsolidation of cued (experiment 1) and contextual (experiment 2) fear memory in rats. Behaviour procedure involved four training phases: habituation, fear conditioning, reactivation and test. Rats were subjected to 6h RSD starting either immediately after reactivation or 6h later. The control rats were returned to their home cages immediately after reactivation and left undisturbed. Contrary to those hypotheses speculating a potential role of sleep in reconsolidation, we found that post-reactivation RSD whether from 0 to 6h or 6 to 12h had no effect on the reconsolidation of both cued and contextual fear memory. However, our present results did not exclude the potential roles of non-rapid eye movement sleep in the reconsolidation of fear memory or sleep in the reconsolidation of other memory paradigms.
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影响因子：
2.7
作者：
C. Bucherelli;G. Tassoni
通讯作者：
C. Bucherelli;G. Tassoni
影响因子：
7.6
作者：
Gu, Chaoliang;Li, Peng;Hu, Xintian
通讯作者：
Hu, Xintian
影响因子：
3.3
作者：
Alvares, L. De Oliveira;Genro, B. Pasqualini;Quillfeldt, J. A.
通讯作者：
Quillfeldt, J. A.
影响因子：
2.7
作者：
Dametto, M;Suchecki, D;Oliveira, MGM
通讯作者：
Oliveira, MGM
影响因子：
56.9
作者：
Eisenberg, M;Kobilo, T;Dudai, Y
通讯作者：
Dudai, Y