Effects of tDCS dose and electrode montage on regional cerebral blood flow and motor behavior.
Effects of tDCS dose and electrode montage on regional cerebral blood flow and motor behavior.
复制标题
DOI：
10.1016/j.neuroimage.2021.118144
复制
发表时间：
2021-08-15
期刊：
影响因子：
5.7
通讯作者：
Schlaug G
中科院分区：
文献类型：
--
作者：
Shinde AB;Lerud KD;Munsch F;Alsop DC;Schlaug G
我们使用三个剂量水平(Sham、2 mA和4 mA)和两个不同的电极蒙太奇(单半球和双半球)来检查剂量和蒙太奇对局部脑血流量(RCBF)的影响，作为神经活动的替代标记，并在手指序列任务上作为替代行为测量，利用经颅直流电刺激(TDC)的脑区。我们将阳极电极放置在右侧运动区(C4)上，而将阴极电极或返回电极放置在左侧眶上区(单半球蒙太奇)或左侧运动区(双半球蒙太奇中的C3)。在双手(左手：P=0.0026，右手：P=0.0002)的手指序列任务中，表现出线性的tDCS剂量反应，但没有蒙太奇效应。在阳极电极下，右侧大脑半球核周区的局部脑血流量随剂量增加而增加(p=0.027)。而在左侧大脑半球周围感兴趣区，局部脑血流量有随剂量增加而增加的趋势(p=0.053)，蒙太奇效应显著(p=0.00004)。在4 mA条件下，双半球蒙太奇显示额内侧区rCBF增加，而在2 mA条件下，rCBF增加不明显。此外，我们还发现，左右两侧指周围区的模拟电流密度与对侧手手指序列任务绩效(FSP)的改善之间存在很强的相关性。我们的数据不仅支持rCBF和FSP作为目标脑区替代指标的强烈直接tDCS剂量效应，而且还支持对功能连接区域(例如额内区)的rCBF的间接影响，特别是在较高剂量条件下，以及对同侧手的FSP(对阳极电极)的影响。在更高的剂量下，无论极性如何，更广泛的感觉运动区网络都会受到tDCs的积极影响。
We used three dose levels (Sham, 2 mA, and 4 mA) and two different electrode montages (unihemispheric and bihemispheric) to examine DOSE and MONTAGE effects on regional cerebral blood flow (rCBF) as a surrogate marker of neural activity, and on a finger sequence task, as a surrogate behavioral measure drawing on brain regions targeted by transcranial direct current stimulation (tDCS). We placed the anodal electrode over the right motor region (C4) while the cathodal or return electrode was placed either over a left supraorbital region (unihemispheric montage) or over the left motor region (C3 in the bihemispheric montage). Performance changes in the finger sequence task for both hands (left hand: p = 0.0026, and right hand: p = 0.0002) showed a linear tDCS dose response but no montage effect. rCBF in the right hemispheric perirolandic area increased with dose under the anodal electrode (p = 0.027). In contrast, in the perirolandic ROI in the left hemisphere, rCBF showed a trend to increase with dose (p = 0.053) and a significant effect of montage (p = 0.00004). The bihemispheric montage showed additional rCBF increases in frontomesial regions in the 4mA condition but not in the 2 mA condition. Furthermore, we found strong correlations between simulated current density in the left and right perirolandic region and improvements in the finger sequence task performance (FSP) for the contralateral hand. Our data support not only a strong direct tDCS dose effect for rCBF and FSP as surrogate measures of targeted brain regions but also indirect effects on rCBF in functionally connected regions (e.g., frontomesial regions), particularly in the higher dose condition and on FSP of the ipsilateral hand (to the anodal electrode). At a higher dose and irrespective of polarity, a wider network of sensorimotor regions is positively affected by tDCS.
登录
查看更多内容
影响因子：
1.7
作者：
Fregni, F;Boggio, PS;Pascual-Leone, A
通讯作者：
Pascual-Leone, A
影响因子：
2.5
作者：
Fricke, K.;Seeber, A. A.;Rothwell, J. C.
通讯作者：
Rothwell, J. C.
影响因子：
7.7
作者：
Ho, Kerrie-Anne;Taylor, Janet L.;Loo, Colleen K.
通讯作者：
Loo, Colleen K.
影响因子：
2.9
作者：
Goodwill AM;Teo WP;Morgan P;Daly RM;Kidgell DJ
通讯作者：
Kidgell DJ
DOI：
10.1016/b978-0-12-802001-2.00005-9
发表时间：
2016-01-01
期刊：
PEDIATRIC BRAIN STIMULATION: MAPPING AND MODULATING THE DEVELOPING BRAIN
影响因子：
--
作者：
Ciechanski, P.;Kirton, A.
通讯作者：
Kirton, A.