Growth differences between North American and European children at risk for type 1 diabetes.
Growth differences between North American and European children at risk for type 1 diabetes.
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DOI：
10.1111/j.1399-5448.2011.00840.x
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发表时间：
2012-08
影响因子：
3.4
通讯作者：
TRIGR Study Group
中科院分区：
文献类型：
--
作者：
Nucci AM;Becker DJ;Virtanen SM;Cuthbertson D;Softness B;Huot C;Wasikowa R;Dosch HM;Akerblom HK;Knip M;TRIGR Study Group
在一组有T1D家族和遗传风险的国际儿童队列中，评估1型糖尿病（T1D）发病率的早期生长与地区差异之间的关系。对参加TRIGR研究的2160名儿童的出生至5岁间的人体测量指数进行了地区间和T1D先证间的比较。北欧儿童在出生至12个月之间的体重z分数最高，而南欧和美国儿童在大多数时间点的体重和长度/身高z分数最低（P<0.005-P<0.001）。母亲T1D状态对体重、身高和BMI的z-score值差异不大。根据国际肥胖工作组的标准，肥胖率一般随年龄增长而增加，北欧男性在5岁时最高（6.0%），加拿大女性最高（12.8%）。不同地理区域间差异无统计学意义。在加拿大，母亲患有和未患有T1D的女性子女在4岁和5岁时的肥胖率差异显著（分别为6.0 vs. 0.0%和21.3% vs. 1.9%， P<0.0125），但在其他地区没有发现母亲患有T1D的差异。与南欧相比，北欧和加拿大的T1D发病率较高，这与儿童早期生长的区域差异是一致的。我们从出生开始的前瞻性研究将允许按地区评估生长与自身免疫发展和T1D进展之间的关系。
To evaluate the relationships between early growth and regional variations in type 1 diabetes (T1D) incidence in an international cohort of children with familial and genetic risk for T1D. Anthropometric indices between birth to 5 years of age were compared amongst regions and T1D proband in 2160 children participating in the TRIGR study. Children in Northern Europe had the highest weight z-score between birth-12 months of age, while those in Southern Europe and the United States had the lowest weight and length/height z-scores at most time points (P<0.005-P<0.001). Few differences in z-score values for weight, height and BMI were found by maternal T1D status. Using International Obesity Task Force criteria, the obesity rates generally increased with age and at 5 years were highest in males in Northern Europe (6.0%) and in females in Canada (12.8%). However, no statistically significance difference was found by geographic region. In Canada, the obesity rate for female children of mothers with and without T1D differed significantly at 4 and 5 years (6.0 vs. 0.0% and 21.3% vs. 1.9%, respectively; P<0.0125) but no differences by maternal T1D status were found in other regions. There are regional differences in early childhood growth that are consistent with the higher incidence of T1D in Northern Europe and Canada as compared to Southern Europe. Our prospective study from birth will allow evaluation of relationships between growth and the emerging development of autoimmunity and progression to T1D by region in this at-risk population of children.
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影响因子：
--
作者：
Wang, Youfa;Lobstein, Tim
通讯作者：
Lobstein, Tim
影响因子：
7.7
作者：
PALMER, JP;HELQVIST, S;NERUP, J
通讯作者：
NERUP, J
影响因子：
7.7
作者：
Wilkin, TJ;Metcalf, BS;Voss, LD
通讯作者：
Voss, LD
影响因子：
8.2
作者：
Dahlquist, GG;Pundziute-Lyckå, A;Nyström, L
通讯作者：
Nyström, L
影响因子：
16.2
作者：
Hyppönen, E;Virtanen, SM;Åkerblom, HK
通讯作者：
Åkerblom, HK