Generation of membrane structures during phagocytosis and chemotaxis of macrophages: role and regulation of the actin cytoskeleton.

Generation of membrane structures during phagocytosis and chemotaxis of macrophages: role and regulation of the actin cytoskeleton.
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DOI:
10.1111/imr.12118
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发表时间:
2013-11
影响因子:
8.7
通讯作者:
Cox D
Cox D
中科院分区:
医学1区
文献类型:
--
作者:
Rougerie P;Miskolci V;Cox D

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Macrophages are best known for their protective search and destroy functions against invading micro-organisms. These processes are commonly known as chemotaxis and phagocytosis. Both of these processes require actin cytoskeletal remodeling to produce distinct F-actin rich membrane structures called lamellipodia and phagocytic cups. This review will focus on the mechanisms by which macrophages regulate actin polymerization through initial receptor signaling and subsequent Arp2/3 activation by nucleation promoting factors like the WASP/WAVE family, followed by remodeling of actin networks to produce these very distinct structures.
肌动蛋白调节波复合物的结构和控制。
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