Generation of membrane structures during phagocytosis and chemotaxis of macrophages: role and regulation of the actin cytoskeleton.
Generation of membrane structures during phagocytosis and chemotaxis of macrophages: role and regulation of the actin cytoskeleton.
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DOI:
10.1111/imr.12118
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发表时间:
2013-11
影响因子:
8.7
通讯作者:
Cox D
中科院分区:
文献类型:
--
作者:
Rougerie P;Miskolci V;Cox D
Macrophages are best known for their protective search and destroy functions against invading micro-organisms. These processes are commonly known as chemotaxis and phagocytosis. Both of these processes require actin cytoskeletal remodeling to produce distinct F-actin rich membrane structures called lamellipodia and phagocytic cups. This review will focus on the mechanisms by which macrophages regulate actin polymerization through initial receptor signaling and subsequent Arp2/3 activation by nucleation promoting factors like the WASP/WAVE family, followed by remodeling of actin networks to produce these very distinct structures.
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影响因子:
64.8
作者:
Chen, Zhucheng;Borek, Dominika;Padrick, Shae B.;Gomez, Timothy S.;Metlagel, Zoltan;Ismail, Ayman M.;Umetani, Junko;Billadeau, Daniel D.;Otwinowski, Zbyszek;Rosen, Michael K.
通讯作者:
Rosen, Michael K.
影响因子:
3.7
作者:
Borm, B;Requardt, RP;Kirfel, G
通讯作者:
Kirfel, G
影响因子:
4.8
作者:
Coppolino, MG;Dierckman, R;Grinstein, S
通讯作者:
Grinstein, S
DOI:
10.1084/jem.184.2.627
发表时间:
1996-08-01
期刊:
The Journal of experimental medicine
影响因子:
--
作者:
Allen LA;Aderem A
通讯作者:
Aderem A
影响因子:
2.8
作者:
Bouma, Gerben;Burns, Siobhan O.;Thrasher, Adrian J.
通讯作者:
Thrasher, Adrian J.