A matched cohort comparison of mTHPC-mediated photodynamic therapy and trans-oral surgery of early stage oral cavity squamous cell cancer.
A matched cohort comparison of mTHPC-mediated photodynamic therapy and trans-oral surgery of early stage oral cavity squamous cell cancer.
复制标题
DOI：
10.1007/s00405-012-2104-6
复制
发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Tan IB
中科院分区：
文献类型：
--
作者：
Karakullukcu B;Stoker SD;Wildeman AP;Copper MP;Wildeman MA;Tan IB
光动力疗法(PDT)治疗早期口腔肿瘤已有较深入的报道。然而，在已出版的文献中，PDT和外科治疗的统计比较是不存在的。我们从一个研究所的经验中确定并匹配了接受手术(n=43)和光动力疗法(n=55)的早期口腔癌患者队列。这两组患者在人口统计学上是匹配的，并有相同的治疗前筛查和后续计划。为了确保可比性，两组都只包括厚度小于5 mm的肿瘤。研究的终点为局部无病生存期、无病生存期、总生存期和对初始治疗的反应。PDT组和手术组5年无瘤生存率分别为67%和74%[单变量HR=61.9(p=0.26)，多变量HR=22.7(p=0.13)]。PDT组和手术组5年无瘤生存率分别为47%和53%[单变量HR=60.8(p=0.52)，多变量HR=60.75(p=0.45)]。PDT组和手术组的总生存率分别为83%和75%[(单变量HR=00.5(p=0.19)，多变量HR=100.5(p=0.17)]。在PDT组，6名患者(11%)和手术组11名患者(26%)在初始治疗后不得不接受额外的治疗。所有被测参数均无统计学意义。尽管由于非随机设计可能存在选择偏差，但这项研究表明，在疾病控制和生存方面，早期口腔癌的PDT与经口腔切除术相当，可以作为手术治疗的替代方案。
Photodynamic therapy (PDT) of early stage oral cavity tumors have been thoroughly reported. However, statistical comparison of PDT to the surgical treatment is not available in published literature. We have identified and matched cohorts of patients with early stage oral cavity cancers undergoing surgery (n = 43) and PDT (n = 55) from a single institute experience. The groups are matched demographically and had the same pre-treatment screening and follow-up schedule. Both groups consisted only of tumors thinner than 5 mm to ensure comparability. The endpoints were local disease free survival, disease free survival, overall survival and response to initial treatment. Local disease free survival at 5 years were 67 and 74 % for PDT and surgery groups, respectively [univariate HR = 1.9 (p = 0.26), multivariable HR = 2.7 (p = 0.13)]. Disease free survival at 5 years are 47 and 53 % for PDT and surgery groups, respectively [univariate HR = 0.8 (p = 0.52), multivariable HR = 0.75 (p = 0.45)]. Overall survival was 83 and 75 % for PDT and surgery groups, respectively [(univariate HR = 0.5 (p = 0.19), multivariable HR = 0.5 (p = 0.17)]. In the PDT group, six patients (11 %) and in the surgery group 11 patients (26 %) had to receive additional treatments after the initial. All of the tested parameters did not have statistical significant difference. Although there is probably a selection bias due to the non-randomized design, this study shows that PDT of early stage oral cavity cancer is comparable in terms of disease control and survival to trans-oral resection and can be offered as an alternative to surgical treatment.
登录
查看更多内容
影响因子：
6.2
作者：
Rusthoven, Kyle;Ballonoff, Ari;Chen, Changhu
通讯作者：
Chen, Changhu
影响因子：
2.6
作者：
Lorenz, Kai Johannes;Maier, Heinz
通讯作者：
Maier, Heinz
影响因子：
6.2
作者：
Huang, Shao Hui;Hwang, David;O'Sullivan, Brian
通讯作者：
O'Sullivan, Brian
影响因子：
6.4
作者：
Hopper, C;Kübler, A;Putnam, G
通讯作者：
Putnam, G
DOI：
10.1002/hed.10372
发表时间：
2004-03-01
影响因子：
2.9
作者：
D'Cruz, AK;Robinson, MH;Biel, MA
通讯作者：
Biel, MA