Alcohol metabolism genes and risks of site-specific cancers in Chinese adults: An 11-year prospective study.
Alcohol metabolism genes and risks of site-specific cancers in Chinese adults: An 11-year prospective study.
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中国成年人酒精代谢基因与部位特异性癌症风险：一项为期11年的前瞻性研究
DOI：
10.1002/ijc.33917
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发表时间：
2022-05-15
影响因子：
6.4
通讯作者：
China Kadoorie Biobank (CKB) Collaborative Group
中科院分区：
文献类型：
--
作者：
Im PK;Yang L;Kartsonaki C;Chen Y;Guo Y;Du H;Lin K;Kerosi R;Hacker A;Liu J;Yu C;Lv J;Walters RG;Li L;Chen Z;Millwood IY;China Kadoorie Biobank (CKB) Collaborative Group
两种改变酒精代谢的遗传变异ALDH 2-rs671和ADH 1B-rs 1229984可以改变东亚人与饮酒相关的食管癌风险，但它们与其他癌症的关系仍不确定。对2004 - 2008年中国10个地区150722名成人进行ALDH 2-rs671 G>A和ADH 1B-rs 1229984 G>A基因分型。经过11年的随访，9339人患上了癌症。使用考克斯回归估计与这些基因型相关的部位特异性癌症的风险比（HR）及其与饮酒的潜在相互作用。总体而言，ALDH 2-rs671和ADH 1B-rs 1229984的A-等位基因频率分别为0.21和0.69，A-等位基因与较低的饮酒量密切相关。在男性中，与GG基因型相比，ALDH 2-rs671 AA基因型与IARC酒精相关癌症（n = 1900）的HR为0.69（95%置信区间：0.53 - 0.90）相关。对于ADH 1B ‐ rs 1229984，AG和AA与GG基因型的HR为0.80（0.69 - 0.93）和0.75（0.64 - 0.87）对于IARC酒精相关癌症，头颈癌（n = 196）为0.61（0.39 - 0.96）和0.61（0.39 - 0.94），食管癌（n = 546）为0.68（0.53 - 0.88）和0.60（0.46 - 0.78）。这些基因型与肝癌（n = 651），结直肠癌（n = 556），胃癌（n = 725）或肺癌（n = 1135）的风险没有显着关联。在男性饮酒者中，ALDH 2-rs671 AG携带者与饮酒量较高相关的头颈癌、食管癌和肺癌风险高于GG携带者（P相互作用< .02）。在女性中，只有2%的人经常饮酒，在基因型和癌症之间没有观察到可比的关联。这些发现支持了饮酒对上呼吸消化道癌症的因果影响，ALDH 2-rs671 AG基因型进一步加剧了风险。 有什么新消息吗？ 中国男性饮酒量一直在增加，是癌症总负担的主要贡献者。两种改变酒精代谢的遗传变异与东亚人的食管癌风险相关。这些变异是否也在其他癌症中发挥作用，或影响酒精对癌症风险的影响？在这项大型中国研究中，作者发现某些基因型与上消化道癌症风险降低相关，其中一种变异可能会加剧酒精对几种癌症的影响。
Two genetic variants that alter alcohol metabolism, ALDH2‐rs671 and ADH1B‐rs1229984, can modify oesophageal cancer risk associated with alcohol consumption in East Asians, but their associations with other cancers remain uncertain. ALDH2‐rs671 G>A and ADH1B‐rs1229984 G>A were genotyped in 150 722 adults, enrolled from 10 areas in China during 2004 to 2008. After 11 years' follow‐up, 9339 individuals developed cancer. Cox regression was used to estimate hazard ratios (HRs) for site‐specific cancers associated with these genotypes, and their potential interactions with alcohol consumption. Overall, the A‐allele frequency was 0.21 for ALDH2‐rs671 and 0.69 for ADH1B‐rs1229984, with A‐alleles strongly associated with lower alcohol consumption. Among men, ALDH2‐rs671 AA genotype was associated with HR of 0.69 (95% confidence interval: 0.53‐0.90) for IARC alcohol‐related cancers (n = 1900), compared to GG genotype. For ADH1B‐rs1229984, the HRs of AG and AA vs GG genotype were 0.80 (0.69‐0.93) and 0.75 (0.64‐0.87) for IARC alcohol‐related cancers, 0.61 (0.39‐0.96) and 0.61 (0.39‐0.94) for head and neck cancer (n = 196) and 0.68 (0.53‐0.88) and 0.60 (0.46‐0.78) for oesophageal cancer (n = 546). There were no significant associations of these genotypes with risks of liver (n = 651), colorectal (n = 556), stomach (n = 725) or lung (n = 1135) cancers. Among male drinkers, the risks associated with higher alcohol consumption were greater among ALDH2‐rs671 AG than GG carriers for head and neck, oesophageal and lung cancers (P interaction < .02). Among women, only 2% drank alcohol regularly, with no comparable associations observed between genotype and cancer. These findings support the causal effects of alcohol consumption on upper aerodigestive tract cancers, with ALDH2‐rs671 AG genotype further exacerbating the risks. What's new? Alcohol consumption has been increasing among men in China, and is a major contributor to the total cancer burden. Two genetic variants that alter alcohol metabolism are associated with esophageal cancer risk in East Asians. Do these variants also play a role in other cancers, or influence the effect of alcohol on cancer risk? In this large Chinese study, the authors found that certain genotypes were associated with reduced upper aero‐digestive tract cancer risk, and that one of the variants may exacerbate the effects of alcohol on several cancers.
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影响因子：
4.6
作者：
Huang C;Sun B;Pan W;Cui J;Wu X;Luo X
通讯作者：
Luo X
影响因子：
6.4
作者：
Im PK;Millwood IY;Kartsonaki C;Chen Y;Guo Y;Du H;Bian Z;Lan J;Feng S;Yu C;Lv J;Walters RG;Li L;Yang L;Chen Z;China Kadoorie Biobank (CKB) Collaborative Group
通讯作者：
China Kadoorie Biobank (CKB) Collaborative Group
影响因子：
3.8
作者：
Lewis, SJ;Smith, GD
通讯作者：
Smith, GD
影响因子：
3.2
作者：
Chen, Junhong;Pan, Weicong;Liu, Kai
通讯作者：
Liu, Kai
DOI：
10.1111/acer.14508
发表时间：
2020-12-16
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Joo Kang, Seung;Shin, Cheol Min;Kim, Nayoung
通讯作者：
Kim, Nayoung