Maternal caffeine intake during pregnancy is associated with risk of low birth weight: a systematic review and dose-response meta-analysis.
Maternal caffeine intake during pregnancy is associated with risk of low birth weight: a systematic review and dose-response meta-analysis.
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DOI：
10.1186/s12916-014-0174-6
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发表时间：
2014-09-19
期刊：
影响因子：
9.3
通讯作者：
van Dam RM
中科院分区：
文献类型：
--
作者：
Chen LW;Wu Y;Neelakantan N;Chong MF;Pan A;van Dam RM
关于母亲怀孕期间咖啡因摄入量与低出生体重（出生体重<2,500 克）风险之间的关系存在相当大的争议。我们的目标是通过前瞻性研究的系统评价和剂量反应荟萃分析来评估这种关联。通过搜索截至 2013 年 7 月 17 日的 MEDLINE 和 SCOPUS 数据库，确定了潜在的文章。两位作者独立提取了有关研究设计、参与者特征和关联估计的信息。使用随机效应模型得出总结相对风险 (RR) 和相应的 95% 置信区间 (CI)。使用广义最小二乘趋势估计来评估剂量-反应关系。在我们的荟萃分析中，我们纳入了 13 项前瞻性研究：9 项以低出生体重作为二元结果变量（90,747 名参与者和 6,303 例病例），6 项以出生体重作为连续结果变量（10,015 名参与者；2 项研究报告了两种类型的结果）。与没有或极低咖啡因摄入量的参考类别相比，低出生体重的 RR (95% CI) 低摄入量（50 至 149 毫克/天）为 1.13（1.06 至 1.21；I2 0.0%），中等摄入量（150 至 349 毫克/天）为 1.38（1.18 至 1.62；I2 31.9%），高摄入量（≥350 毫克/天）为 1.60（1.24 至 2.08；I2 65.8%）。在剂量反应分析中，母亲每天咖啡因摄入量（大约一杯咖啡）每增加 100 毫克，低出生体重风险就会增加 13%（RR 1.13、1.06 至 1.21）。这种关联在根据各种研究特征定义的层中持续存在。与参考类别相比，中度（−33 g，95% CI -63 至 -4；I2 0.3%）和高（−69 g，95% CI -102 至 -35；I2 0.0%）咖啡因摄入量也与出生体重显着降低相关。怀孕期间母亲咖啡因摄入量较高与生出低出生体重婴儿的风险较高相关。这些发现支持将怀孕期间咖啡因摄入量限制在较低水平的建议。本文的在线版本 (doi:10.1186/s12916-014-0174-6) 包含补充材料，可供授权用户使用。
Considerable controversy exists regarding the relation between maternal caffeine intake during pregnancy and risk of low birth weight (birth weight <2,500 g). We aim to assess this association using a systematic review and dose–response meta-analysis of prospective studies. Potential articles were identified by searching MEDLINE and SCOPUS databases through 17 July 2013. Two authors independently extracted information on study design, participant characteristics and estimates of associations. Random-effects models were used to derive the summary relative risks (RRs) and corresponding 95% confidence intervals (CIs). Dose–response relationships were assessed using generalized least-squares trend estimation. In our meta-analysis, we included 13 prospective studies: 9 with low birth weight as a binary outcome variable (90,747 participants and 6,303 cases) and 6 with birth weight as a continuous outcome variable (10,015 participants; 2 studies reported both types of outcomes). Compared with the reference category with no or very low caffeine intake, the RR (95% CI) of low birth weight was 1.13 (1.06 to 1.21; I2 0.0%) for low intake (50 to 149 mg/day), 1.38 (1.18 to 1.62; I2 31.9%) for moderate intake (150 to 349 mg/day), and 1.60 (1.24 to 2.08; I2 65.8%) for high intake (≥350 mg/day). In the dose–response analysis, each 100-mg/day increment in maternal caffeine intake (around one cup of coffee) was associated with 13% (RR 1.13, 1.06 to 1.21) higher risk of low birth weight. The association persisted in strata defined according to various study characteristics. Moderate (−33 g, 95% CI −63 to −4; I2 0.3%) and high (−69 g, 95% CI −102 to −35; I2 0.0%) caffeine intakes were also associated with a significantly lower birth weight as compared with the reference category. Higher maternal caffeine intake during pregnancy was associated with a higher risk of delivering low birth weight infants. These findings support recommendations to restrict caffeine intake during pregnancy to low levels. The online version of this article (doi:10.1186/s12916-014-0174-6) contains supplementary material, which is available to authorized users.
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影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
影响因子：
4
作者：
Eteng, MU;Eyong, EU;Aremu, CY
通讯作者：
Aremu, CY
DOI：
10.1159/000457332
发表时间：
1983-01-01
期刊：
DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS
影响因子：
--
作者：
BRAZIER, JL;RITTER, J;FAUCON, G
通讯作者：
FAUCON, G
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
105.7
作者：
BROOKE, OG;ANDERSON, HR;STEWART, CM
通讯作者：
STEWART, CM