Association Between Extracellular Superoxide Dismutase Activity and 1-Year All-Cause Mortality in Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study.
Association Between Extracellular Superoxide Dismutase Activity and 1-Year All-Cause Mortality in Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study.
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DOI：
10.3389/fmed.2022.811975
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发表时间：
2022
影响因子：
3.9
通讯作者：
Ran P
中科院分区：
文献类型：
--
作者：
Li H;Hong W;Zeng Z;Gong S;Wu F;Wang Z;Tian H;Cheng J;Sun R;Gao M;Liang C;Cao W;Hu G;Li Y;Wei L;Zhou Y;Ran P
越来越多的证据表明，氧化应激参与慢性阻塞性肺疾病(COPD)的发生和发展。细胞外超氧化物歧化酶(EcSOD)是唯一清除超氧阴离子自由基的胞外酶，据报道在COPD急性加重期(AECOPD)时其活性下降。然而，在AECOPD患者中，血清EcSOD活性与1年全因死亡率之间的关联仍不清楚。我们研究的目的是探讨AECOPD患者入院时ECSOD活性作为一年全因死亡率的客观预测指标的有用性。在一项前瞻性队列研究中，我们测量了AECOPD患者入院时的血清ECSOD活性。我们还记录了他们的实验室和临床数据。采用多变量COX回归分析ECSOD活性与1年全因死亡风险之间的关系。采用限制性三次样条曲线对ECSOD活性与1年全因死亡风险比之间的关系进行可视化分析。共有367名患者被随访1年，29名患者在1年的随访期内死亡。与幸存者相比，死亡者年龄更大(79.52vs.74.38.39vs.74.38±9.34年，p=0.004)，烟草消费水平增加(47.07vs.33.831.79年，p=0.037)。在调整基线差异、临床变量和合并症后，ECSOD活性≤为98.8U/ml是1年全因死亡率的独立危险因素[危险比=5.51，95%可信区间：2.35~12.95，p<；0.001]。血清ECSOD活性降低是AECOPD患者1年内全因死亡率的独立预测因子。
Accumulating evidence suggests that oxidative stress is involved in the development of chronic obstructive pulmonary disease (COPD) and its progression. Activity of extracellular superoxide dismutase (ecSOD), the only extracellular enzyme eliminating superoxide radicals, has been reported to decline in acute exacerbations of COPD (AECOPD). However, the association between serum ecSOD activity and 1-year all-cause mortality in AECOPD patients remains unclear. The objective of our study was to explore the usefulness of ecSOD activity on admission in AECOPD as an objective predictor for 1-year all-cause mortality. We measured serum ecSOD activity in AECOPD patients on admission in a prospective cohort study. We also recorded their laboratory and clinical data. Multivariate Cox regression was used to analyze the association between ecSOD activity and the risk of 1-year all-cause mortality. Restricted cubic spline curves were used to visualize the relationship between ecSOD activity and the hazard ratio of 1-year all-cause mortality. A total of 367 patients were followed up for 1 year, and 29 patients died during a 1-year follow-up period. Compared with survivors, the non-survivors were older (79.52 ± 8.39 vs. 74.38 ± 9.34 years old, p = 0.004) and had increased levels of tobacco consumption (47.07 ± 41.67 vs. 33.83 ± 31.79 pack-years, p = 0.037). Having an ecSOD activity ≤ 98.8 U/ml was an independent risk factor of 1-year all-cause mortality after adjustment for baseline differences, clinical variables and comorbidities [hazard ratio = 5.51, 95% confidence interval (CI): 2.35–12.95, p < 0.001]. Lower serum ecSOD activity was a strong and independent predictor of 1-year all-cause mortality in AECOPD patients.
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影响因子：
24.3
作者：
Gopal, Poornima;Reynaert, Niki L.;Rutten, Erica P. A.
通讯作者：
Rutten, Erica P. A.
影响因子：
9.6
作者：
Moll, Matthew;Qiao, Dandi;Cho, Michael H.
通讯作者：
Cho, Michael H.
影响因子：
11.4
作者：
Bar-Or, David;Bar-Or, Raphael;Rael, Leonard T.;Brody, Edward N.
通讯作者：
Brody, Edward N.
影响因子：
3.9
作者：
McGuinness AJ;Sapey E
通讯作者：
Sapey E
DOI：
10.1164/rccm.200509-1387oc
发表时间：
2006-04-15
影响因子：
24.7
作者：
Juul, K;Tybjærg-Hansen, A;Nordestgaard, BG
通讯作者：
Nordestgaard, BG