Cognition, glucose metabolism and amyloid burden in Alzheimer's disease.
Cognition, glucose metabolism and amyloid burden in Alzheimer's disease.
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DOI：
10.1016/j.neurobiolaging.2010.03.011
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发表时间：
2012-02
影响因子：
4.2
通讯作者：
Jagust WJ
中科院分区：
文献类型：
--
作者：
Furst AJ;Rabinovici GD;Rostomian AH;Steed T;Alkalay A;Racine C;Miller BL;Jagust WJ
我们研究了阿尔茨海默病 (AD) 中葡萄糖代谢、淀粉样蛋白负荷与认知和功能损害指标之间的关系。符合可能 AD 标准的患者接受了 [11C]PIB 和 [18F]FDG PET 成像，并根据一组临床指标进行评估。 PIB 分布体积比和 FDG 扫描在空间上标准化，并且使用感兴趣区域 (ROI) 的平均 PIB 计数来计算全局 PIB 吸收的度量。单独的体素回归探索了代谢、淀粉样蛋白负荷和临床测量之间的局部和整体关系。回归反映了通过个体测量评估的认知领域，其中视觉空间测试与更多后代谢相关，语言测试与左半球的新陈代谢相关。将区域 FDG 吸收率与这些措施相关联证实了这些发现。相比之下，在体素或区域 PIB 摄取与任何临床测量之间没有发现相关性。最后，区域 PIB 和 FDG 吸收之间没有关联。我们的结论是，区域和整体淀粉样蛋白负荷与 AD 的临床状态或葡萄糖代谢无关。
We investigated relationships between glucose metabolism, amyloid load and measures of cognitive and functional impairment in Alzheimer’s disease (AD). Patients meeting criteria for probable AD underwent [11C]PIB and [18F]FDG PET imaging and were assessed on a set of clinical measures. PIB Distribution volume ratios and FDG scans were spatially normalized and average PIB counts from regions-of-interest (ROI) were used to compute a measure of global PIB uptake. Separate voxel-wise regressions explored local and global relationships between metabolism, amyloid burden and clinical measures. Regressions reflected cognitive domains assessed by individual measures, with visuospatial tests associated with more posterior metabolism, and language tests associated with metabolism in the left hemisphere. Correlating regional FDG uptake with these measures confirmed these findings. In contrast, no correlations were found between either voxel-wise or regional PIB uptake and any of the clinical measures. Finally, there were no associations between regional PIB and FDG uptake. We conclude that regional and global amyloid burden does not correlate with clinical status or glucose metabolism in AD.
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影响因子：
9.9
作者：
Boxer, A. L.;Rabinovici, G. D.;Miller, B. L.
通讯作者：
Miller, B. L.
淀粉样蛋白β动力学与受伤的人脑中的神经系统状况相关。
影响因子：
56.9
作者：
Brody, David L.;Magnoni, Sandra;Schwetye, Kate E.;Spinner, Michael L.;Esparza, Thomas J.;Stocchetti, Nino;Zipfel, Gregory J.;Holtzman, David M.
通讯作者：
Holtzman, David M.
影响因子：
4.2
作者：
Duyckaerts, C;Bennecib, M;Hauw, JJ
通讯作者：
Hauw, JJ
影响因子：
3.7
作者：
Arnold, Steven E.;Hyman, Bradley T.;Van Hoesen, Gary W.
通讯作者：
Van Hoesen, Gary W.
影响因子：
--
作者：
Aizenstein, Howard Jay;Nebes, Robert D.;Saxton, Judith A.;Price, Julie C.;Mathis, Chester A.;Tsopelas, Nicholas D.;Ziolko, Scott K.;James, Jeffrey A.;Snitz, Beth E.;Houck, Patricia R.;Bi, Wenzhu;Cohen, Ann D.;Lopresti, Brian J.;DeKosky, Steven T.;Halligan, Edythe M.;Klunk, William E.
通讯作者：
Klunk, William E.