Xiaoyaosan Exerts Antidepressant Effect by Downregulating RAGE Expression in Cingulate Gyrus of Depressive-Like Mice.
Xiaoyaosan Exerts Antidepressant Effect by Downregulating RAGE Expression in Cingulate Gyrus of Depressive-Like Mice.
复制标题
逍遥散通过下调抑郁样小鼠扣带回RAGE表达发挥抗抑郁作用
DOI：
10.3389/fphar.2021.703965
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发表时间：
2021
影响因子：
5.6
通讯作者：
Lv Z
中科院分区：
文献类型：
--
作者：
Yan W;Dong Z;Zhao D;Li J;Zeng T;Mo C;Gao L;Lv Z
逍遥散作为一种经典中药复方，已被大量研究证实具有抗抑郁作用，但其作用机制尚未阐明。我们在前期的研究中发现，慢性应激可诱导抑郁样行为，导致情绪相关的扣带回功能障碍，以及神经营养因子的减少和炎症相关蛋白的增加。因此，我们推测XYS可能通过调节炎症相关受体晚期糖基化蛋白终产物（Advanced Glycation protein end product，CYP）影响Cg的功能连接（functional connectivity，FC）信号，改善抑郁样行为而发挥抗抑郁作用。为了验证这一假设，我们分析了慢性不可预测的轻度应激（CIMS）诱导的抑郁样小鼠Cg中FC和Cg的表达，并用Cg基因敲除小鼠进行了验证。同时检测XYS对小鼠抑郁样行为、海马CA1区mRNA表达及Cg区FC的影响。结果表明，Bismuth S诱导的抑郁样小鼠Cg的FC减弱，Bismuth的表达上调。XYS的抗抑郁作用与盐酸氟西汀相似，能显著减轻小鼠的抑郁样行为，抑制Cg中Cg蛋白和mRNA的表达，增加Cg的FC。结论：XYS可能通过下调Cg中Cg的表达，影响功能信号，改善抑郁样行为，从而发挥抗抑郁作用。
Xiaoyaosan (XYS), as a classic Chinese medicine compound, has been proven to have antidepressant effect in many studies, but its mechanism has not been clarified. In our previous studies, we found that chronic stress can induce depressive-like behavior and lead to emotion-related cingulate gyrus (Cg) dysfunction, as well as the decrease of neurotrophic factors and the increase of inflammatory-related proteins. Therefore, we speculated that XYS may play an antidepressant role by regulating the inflammation-related receptor of advanced glycation protein end product (RAGE) to affect the functional connectivity (FC) signal of the Cg and improve the depressive-like behavior. In order to verify this hypothesis, we analyzed the FC and RAGE expression in the Cg of depressive-like mice induced by chronic unpredictable mild stress (CUMS) and verified it with RAGE knockout mice. At the same time, we detected the effect of XYS on the depressive-like behavior, expression of RAGE, and the FC of the Cg of mice. The results showed that the FC of the Cg of depressive-like mice induced by CUMS was weakened, and the expression of RAGE was upregulated. The antidepressant effect of XYS is similar to that of fluoxetine hydrochloride, which can significantly reduce the depressive-like behavior of mice and inhibit the expression of the RAGE protein and mRNA in the Cg, and increase the FC of the Cg in mice. In conclusion, XYS may play an antidepressant role by downregulating the expression of RAGE in the Cg of depressive-like mice induced by CUMS, thereby affecting the functional signal and improving the depressive-like behavior.
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影响因子：
10.6
作者：
Miller, Andrew H.;Maletic, Vladimir;Raison, Charles L.
通讯作者：
Raison, Charles L.
加味逍遥散 (MXYS) 通过纠正脑血氧水平依赖性 fMRI 信号并改善小鼠海马神经发生发挥抗抑郁作用
影响因子：
5.6
作者：
Gao L;Huang P;Dong Z;Gao T;Huang S;Zhou C;Lai Y;Deng G;Liu B;Wen G;Lv Z
通讯作者：
Lv Z
影响因子：
11
作者：
Felger JC;Haroon E;Patel TA;Goldsmith DR;Wommack EC;Woolwine BJ;Le NA;Feinberg R;Tansey MG;Miller AH
通讯作者：
Miller AH
DOI：
10.1016/j.bbi.2015.06.001
发表时间：
2015-10
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Haapakoski R;Mathieu J;Ebmeier KP;Alenius H;Kivimäki M
通讯作者：
Kivimäki M
逍遥散通过调节蓝斑-去甲肾上腺素系统改善慢性固定应激大鼠的抑郁样行为
DOI：
10.1155/2014/605914
发表时间：
2014
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Ding XF;Zhao XH;Tao Y;Zhong WC;Fan Q;Diao JX;Liu YL;Chen YY;Chen JX;Lv ZP
通讯作者：
Lv ZP