Xiao Yao San Improves Depressive-Like Behaviors in Rats with Chronic Immobilization Stress through Modulation of Locus Coeruleus-Norepinephrine System.
Xiao Yao San Improves Depressive-Like Behaviors in Rats with Chronic Immobilization Stress through Modulation of Locus Coeruleus-Norepinephrine System.
复制标题
逍遥散通过调节蓝斑-去甲肾上腺素系统改善慢性固定应激大鼠的抑郁样行为
DOI：
10.1155/2014/605914
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Lv ZP
中科院分区：
文献类型：
--
作者：
Ding XF;Zhao XH;Tao Y;Zhong WC;Fan Q;Diao JX;Liu YL;Chen YY;Chen JX;Lv ZP
应激引起的情绪和行为异常主要集中在下丘脑-垂体-肾上腺(HPA)轴、下丘脑-垂体-甲状腺(HPT)轴和下丘脑-垂体-性腺(HPGA)轴系统，而逍遥散等中药对蓝斑-去甲肾上腺素(LC-NE)系统的研究尚未见报道。因此，本实验旨在观察LC-NE系统对慢性束缚应激的反应机制，并探讨XYS的抗抑郁作用。用CIS建立大鼠模型。对大鼠进行LC形态学观察。测定各组大鼠血清去甲肾上腺素(NE)浓度及血清中酪氨酸羟化酶(TH)、多巴胺β羟基酶(DBH)、促肾上腺皮质激素释放因子(CRF)等去甲肾上腺素的生物合成。结果表明，大鼠LC无明显变化。模型组大鼠血清NE浓度、阳性神经元数、平均光密度(MOD)及TH、DBH、CRF蛋白水平均显著高于对照组。与模型组比较，XYS治疗组去甲肾上腺素(NE)水平及TH、DBH、CRF表达均显著降低。结论：顺铂可激活LC-NE系统释放去甲肾上腺素，使大鼠体内去甲肾上腺素水平显著降低。XYS治疗可通过抑制LC-NE神经元的活动，有效改善大鼠的抑郁样行为。
Most research focuses on the hypothalamic-pituitary-adrenal (HPA) axis, hypothalamus-pituitary-thyroid (HPT) axis, and hypothalamus-pituitary-gonadal (HPGA) axis systems of abnormalities of emotions and behaviors induced by stress, while no studies of Chinese herbal medicine such as Xiao Yao San (XYS) on the mechanisms of locus coeruleus-norepinephrine (LC-NE) system have been reported. Therefore, experiments were carried out to observe mechanism of LC-NE system in response to chronic immobilization stress (CIS) and explore the antidepressant effect of XYS. Rat model was established by CIS. LC morphology in rat was conducted. The serum norepinephrine (NE) concentrations and NE biosynthesis such as tyrosine hydroxylase (TH), dopamine-β-hydroxylase (DBH), and corticotrophin-releasing-factor (CRF) in LC were determined. Results showed that there were no discernible alterations in LC in rats. The serum NE concentrations, positive neurons, mean optical density (MOD), and protein levels of TH, DBH, and CRF in model group were significantly increased compared to the control group. But XYS-treated group displayed a significantly decreased in NE levels and expressions of TH, DBH, and CRF compared to the model group. In conclusion, CIS can activate LC-NE system to release NE and then result in a significant decrease in rats. XYS treatment can effectively improve depressive-like behaviors in rats through inhibition of LC-NE neurons activity.
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影响因子：
10.6
作者：
Koob, GF
通讯作者：
Koob, GF
星形胶质细胞衍生的 ATP 调节抑郁样行为
影响因子：
82.9
作者：
Cao, Xiong;Li, Liang-Ping;Gao, Tian-Ming
通讯作者：
Gao, Tian-Ming
DOI：
10.1155/2013/984797
发表时间：
2013
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Liang Y;Guo XL;Chen JX;Yue GX
通讯作者：
Yue GX
影响因子：
7.6
作者：
Devilbiss, David M.;Waterhouse, Barry D.;Valentino, Rita
通讯作者：
Valentino, Rita
影响因子：
2.5
作者：
PAGE, ME;BERRIDGE, CW;VALENTINO, RJ
通讯作者：
VALENTINO, RJ