MicroRNAs in mental health: from biological underpinnings to potential therapies.
MicroRNAs in mental health: from biological underpinnings to potential therapies.
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DOI：
10.1007/s12017-009-8070-5
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发表时间：
2009
影响因子：
3.5
通讯作者：
Manji, Husseini K.
中科院分区：
文献类型：
--
作者：
Hunsberger, Joshua G.;Austin, Daniel R.;Chen, Guang;Manji, Husseini K.
关键词：
精神疾病是一种致残性疾病，其潜在的病理生理机制知之甚少。然而，越来越明显的是，这些疾病是由整个细胞网络的破坏引起的，而不是任何特定的单胺系统。最近的证据继续支持这一假设，即这些疾病是由细胞可塑性级联损伤引起的，这导致调节情绪、认知和神经植物功能（睡眠、食欲、能量等）的回路中的异常信息处理。因此，许多人开始考虑未来的疗法，这些疗法能够影响细胞可塑性的整体变化，以恢复适当的突触功能和神经元连接。microRNA（miRNAs）是一种非编码RNA，可以抑制数百种靶标的基因翻译，因此可以很好地靶向多种细胞机制。在这里，我们回顾了microRNA的一些特性，并表明它们被压力，糖皮质激素，情绪稳定剂以及特定的精神疾病精神分裂症所改变。虽然这一领域仍处于起步阶段，但我们认为它们具有调节行为表型和靶向与精神疾病有关的关键预测信号级联的潜力。显然，需要大量的研究来更好地确定靶向microRNA的任何治疗潜力;然而，这些药物可能为精神疾病提供下一代有效的治疗方法。
Psychiatric illnesses are disabling disorders with poorly understood underlying pathophysiologies. However, it is becoming increasingly evident that these illnesses result from disruptions across whole cellular networks rather than any particular monoamine system. Recent evidence continues to support the hypothesis that these illnesses arise from impairments in cellular plasticity cascades, which lead to aberrant information processing in the circuits that regulate mood, cognition, and neurovegetative functions (sleep, appetite, energy, etc). As a result, many have begun to consider future therapies that would be capable of affecting global changes in cellular plasticity to restore appropriate synaptic function and neuronal connectivity. MicroRNAs (miRNAs) are non-coding RNAs that can repress the gene translation of hundreds of their targets and are therefore well-positioned to target a multitude of cellular mechanisms. Here, we review some properties of microRNAs and show they are altered by stress, glucocorticoids, mood stabilizers, and in a particular psychiatric disorder, schizophrenia. While this field is still in its infancy, we consider their potential for regulating behavioral phenotypes and targeting key predicted signaling cascades that are implicated in psychiatric illness. Clearly, considerable research is required to better determine any therapeutic potential of targeting microRNAs; however, these agents may provide the next generation of effective therapies for psychiatric illnesses.
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影响因子：
6.9
作者：
Chen, G;Manji, HK
通讯作者：
Manji, HK
DOI：
10.1080/10253890802046281
发表时间：
2009-01
影响因子：
2.3
作者：
Grippo, Angela J.;Johnson, Alan Kim
通讯作者：
Johnson, Alan Kim
大脑表达的microRNA与精神分裂症病因有关。
影响因子：
3.7
作者：
Hansen, Thomas;Olsen, Line;Lindow, Morten;Jakobsen, Klaus D.;Ullum, Henrik;Jonsson, Erik;Andreassen, Ole A.;Djurovic, Srdjan;Melle, Ingrid;Agartz, Ingrid;Hall, Hakan;Timm, Sally;Wang, August G.;Werge, Thomas
通讯作者：
Werge, Thomas
影响因子：
3.5
作者：
Duman, RS
通讯作者：
Duman, RS
影响因子：
3.3
作者：
Drevets, Wayne C.;Savitz, Jonathan
通讯作者：
Savitz, Jonathan