Stress, depression and cardiovascular dysregulation: a review of neurobiological mechanisms and the integration of research from preclinical disease models.
Stress, depression and cardiovascular dysregulation: a review of neurobiological mechanisms and the integration of research from preclinical disease models.
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DOI：
10.1080/10253890802046281
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发表时间：
2009-01
影响因子：
2.3
通讯作者：
Johnson, Alan Kim
中科院分区：
文献类型：
--
作者：
Grippo, Angela J.;Johnson, Alan Kim
关键词：
抑郁症等情绪障碍与心肌梗塞和充血性心力衰竭等心血管疾病之间存在双向关联。然而，这些关联背后的确切神经生物学机制尚未完全阐明。本综述的重点是情绪和心血管疾病常见的神经生物学过程和介质，除了以下外源性应激源的作用外，还重点关注：（a）涉及下丘脑-垂体-肾上腺轴功能障碍和肾素-血管紧张素-醛固酮系统激活的神经内分泌和神经体液变化，（b）免疫改变 包括促炎细胞因子的激活，（c）自主神经和心血管失调，包括交感神经驱动力增强、副交感神经张力减弱、心率和节律紊乱以及压力感受器反射功能改变，（d）中枢神经递质系统功能障碍，包括多巴胺、去甲肾上腺素和血清素，以及（e）行为改变，包括疲劳和 身体不活动。我们还特别关注临床前疾病模型的实验研究，旨在阐明情绪障碍与心血管疾病之间联系的神经生物学机制。这些包括：（a）抑郁症慢性轻度应激模型，（b）充血性心力衰竭模型，心血管功能失调模型，（d）体液和钠平衡的药理学操作，以及（e）中枢血清素能系统的药理学操作。结合描述人类研究结果的大量文献，使用动物模型研究情绪和心血管调节的机制将增强我们对抑郁症和心血管疾病之间关系的理解，并可以促进针对患有这些共病的个体开发更好的治疗和干预措施。
A bidirectional association between mood disorders such as depression, and cardiovascular diseases such as myocardial infarction and congestive heart failure, has been described; however, the precise neurobiological mechanisms that underlie these associations have not been fully elucidated. This review is focused on the neurobiological processes and mediators that are common to both mood and cardiovascular disorders, with an emphasis on the role of exogenous stressors in addition to: (a) neuroendocrine and neurohumoral changes involving dysfunction of the hypothalamic-pituitary-adrenal axis and activation of the renin-angiotensin-aldosterone system, (b) immune alterations including activation of pro-inflammatory cytokines, (c) autonomic and cardiovascular dysregulation including increased sympathetic drive, withdrawal of parasympathetic tone, cardiac rate and rhythm disturbances, and altered baroreceptor reflex function, (d) central neurotransmitter system dysfunction including dopamine, norepinephrine and serotonin, and (e) behavioral changes including fatigue and physical inactivity. We also focus specifically on experimental investigations with preclinical disease models, conducted to elucidate the neurobiological mechanisms underlying the link between mood disorders and cardiovascular disease. These include: (a) the chronic mild stress model of depression, (b) a model of congestive heart failure, a model of cardiovascular deconditioning, (d) pharmacological manipulations of body fluid and sodium balance, and (e) pharmacological manipulations of the central serotonergic system. In combination with the extensive literature describing findings from human research, the investigation of mechanisms underlying mood and cardiovascular regulation using animal models will enhance our understanding of the association of depression and cardiovascular disease, and can promote the development of better treatments and interventions for individuals with these co-morbid conditions.
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影响因子：
37.8
作者：
Barefoot, JC;Schroll, M
通讯作者：
Schroll, M
影响因子：
4.8
作者：
BAGDY, G;MAKARA, GB
通讯作者：
MAKARA, GB
影响因子：
--
作者：
BATAILLARD, A;DELREY, A;BESEDOVSKY, HO
通讯作者：
BESEDOVSKY, HO
影响因子：
10.5
作者：
BIDZINSKA, EJ
通讯作者：
BIDZINSKA, EJ
影响因子：
5.4
作者：
ANDA, R;WILLIAMSON, D;MARKS, J
通讯作者：
MARKS, J